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. 2024 Mar;69(1):56-66.
doi: 10.1111/adj.12985. Epub 2023 Oct 9.

The effect of silver nanoparticles in addition to sodium fluoride on remineralization of artificial root dentin caries

P Kongyodsueb  1 , S Poolthong  1 , S Chumprasert  2 , P Sae-Ear  2 , Y Tantilertanant  1
Affiliations

The effect of silver nanoparticles in addition to sodium fluoride on remineralization of artificial root dentin caries

P Kongyodsueb et al. Aust Dent J. 2024 Mar.

Abstract

Background: Silver nanoparticle was developed to overcome the drawback of silver diamine fluoride. However, evidence is limited, especially in root caries. The aim of this study was to evaluate the remineralization effect of silver nanoparticles on root caries.

Materials and methods: Fifty-five root human dentin slices size 5 × 5 mm2 from patients aged over 60 years old were immersed in demineralized solution to create artificial caries. Specimens were allocated into five groups according to the remineralizing agents: silver diamine fluoride (SDF), silver nanoparticles solution (AgNPs), silver nanoparticle solution followed by sodium fluoride varnish (AgNPs+NaF), sodium fluoride varnish (NaF), and tap water. After 8 days of pH-cycling challenge, the microhardness test, lesion depth evaluation, dentin surface morphology, and elemental analysis were performed. Data was analysed using F-test One-way ANOVA followed by Tukey's post hoc test and paired T-test.

Results: All test groups demonstrated a significantly higher microhardness value and lower lesion depth compared with the control group. AgNPs+NaF and NaF-treated groups showed lower efficacy than SDF. Crystal precipitation was presented in all groups composed of silver.

Conclusion: Addition of fluoride varnish did not benefit for silver nanoparticles in preventing further demineralization. SDF provides the highest effectiveness in elderly root carious dentin.

Keywords: caries prevention; elderly root dentin; silver diamine fluoride; silver nanoparticles; sodium fluoride.

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References

REFERENCES

    1. World population prospects 2019. United Nation, New York: Department of Economic and social affairs, Population Division, 2019.
    1. Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of untreated caries: a systematic review and metaregression. J Dent Res 2015;94:650-658.
    1. Wierichs RJ, Meyer-Lueckel H. Systematic review on noninvasive treatment of root caries lesions. J Dent Res 2015;94:261-271.
    1. Gluzman R, Katz RV, Frey BJ, McGowan R. Prevention of root caries: a literature review of primary and secondary preventive agents. Spec Care Dentist 2013;33:133-140.
    1. Ravald N, Birkhed D. Prediction of root caries in periodontally treated patients maintained with different fluoride programmes. Caries Res 1992;26:450-458.

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