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. 1986 Jun-Jul;24(6-7):457-63.
doi: 10.1016/0278-6915(86)90092-x.

The FRAME multicentre project on in vitro cytotoxicology

P Knox, P F Uphill, J R Fry, J Benford, M Balls

The FRAME multicentre project on in vitro cytotoxicology

P Knox et al. Food Chem Toxicol. 1986 Jun-Jul.

Abstract

An in vitro method for assessing the relative acute toxicities of chemicals was developed through the collaboration of four tissue culture laboratories. Cytotoxicity was measured by using a dye-binding method to determine inhibition of the proliferation of BCL-D1 cells 72 hr after addition of the test chemical. A blind trial with 50 chemicals showed that the test procedure gave results with a high degree of interlaboratory reproducibility.

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