Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research

Maria C Costanzo¹, Carolina Roselli^{2

3}, MacKenzie Brandes¹, Marc Duby¹, Quy Hoang¹, Dongkeun Jang¹, Ryan Koesterer¹, Parul Kudtarkar⁴, Annie Moriondo¹, Trang Nguyen¹, Oliver Ruebenacker¹, Patrick Smadbeck¹, Ying Sun⁴, Adam S Butterworth^{5

6

7

8

9

10}, Krishna G Aragam^{11

12

13

14}, R Thomas Lumbers^{15

16

17

18}, Amit V Khera^{19

20}, Steven A Lubitz²¹, Patrick T Ellinor^{11

13

21}, Kyle J Gaulton⁴, Jason Flannick^{1

22

23}, Noël P Burtt¹

Affiliations

¹ Programs in Metabolism and Medical and Population Genetics (M.C.C., M.B., M.D., Q.H., D.J., R.K., A.M., T.N., O.R., P.S., J.F., N.P.B.), The Broad Institute of MIT and Harvard, Cambridge, MA.
² Precision Cardiology Laboratory (C.R.), The Broad Institute of MIT and Harvard, Cambridge, MA.
³ Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (C.R.).
⁴ Department of Pediatrics, University of California San Diego, La Jolla (P.K., Y.S., K.J.G.).
⁵ BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (A.S.B.).
⁶ NIHR Blood & Transplant Research Unit in Donor Health & Behaviour, Department of Public Health & Primary Care (A.S.B.).
⁷ Victor Phillip Dahdaleh Heart & Lung Research Institute (A.S.B.).
⁸ Health Data Research UK Cambridge (A.S.B.).
⁹ University of Cambridge (A.S.B.).
¹⁰ British Heart Foundation Cambridge Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, United Kingdom (A.S.B.).
¹¹ Cardiovascular Disease Initiative (K.G.A., P.T.E.), The Broad Institute of MIT and Harvard, Cambridge, MA.
¹² Program in Medical & Population Genetics (K.G.A.), The Broad Institute of MIT and Harvard, Cambridge, MA.
¹³ Cardiovascular Research Center (K.G.A., P.T.E.), Massachusetts General Hospital, Boston.
¹⁴ Center for Genomic Medicine (K.G.A.), Massachusetts General Hospital, Boston.
¹⁵ British Heart Foundation Research Accelerator (R.T.L.), University College London.
¹⁶ Institute of Health Informatics (R.T.L.), University College London.
¹⁷ Health Data Rsrch UK London (R.T.L.), University College London.
¹⁸ Bart's Heart Center, St. Bartholomew's Hospital, London, United Kingdom (R.T.L.).
¹⁹ Verve Therapeutics (A.V.K.).
²⁰ Division of Cardiology, Brigham and Women's Hospital (A.V.K.).
²¹ Demoulas Center for Cardiac Arrhythmias (S.A.L., P.T.E.), Massachusetts General Hospital, Boston.
²² Department of Pediatrics, Boston Children's Hospital (J.F.).
²³ Department of Pediatrics, Harvard Medical School, Boston, MA (J.F.).

PMID: 37814896
PMCID: PMC10843166
DOI: 10.1161/CIRCGEN.123.004181

Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research

Maria C Costanzo et al. Circ Genom Precis Med. 2023 Dec.

. 2023 Dec;16(6):e004181.

doi: 10.1161/CIRCGEN.123.004181. Epub 2023 Oct 10.

Authors

Affiliations

¹ Programs in Metabolism and Medical and Population Genetics (M.C.C., M.B., M.D., Q.H., D.J., R.K., A.M., T.N., O.R., P.S., J.F., N.P.B.), The Broad Institute of MIT and Harvard, Cambridge, MA.
² Precision Cardiology Laboratory (C.R.), The Broad Institute of MIT and Harvard, Cambridge, MA.
³ Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (C.R.).
⁴ Department of Pediatrics, University of California San Diego, La Jolla (P.K., Y.S., K.J.G.).
⁵ BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (A.S.B.).
⁶ NIHR Blood & Transplant Research Unit in Donor Health & Behaviour, Department of Public Health & Primary Care (A.S.B.).
⁷ Victor Phillip Dahdaleh Heart & Lung Research Institute (A.S.B.).
⁸ Health Data Research UK Cambridge (A.S.B.).
⁹ University of Cambridge (A.S.B.).
¹⁰ British Heart Foundation Cambridge Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, United Kingdom (A.S.B.).
¹¹ Cardiovascular Disease Initiative (K.G.A., P.T.E.), The Broad Institute of MIT and Harvard, Cambridge, MA.
¹² Program in Medical & Population Genetics (K.G.A.), The Broad Institute of MIT and Harvard, Cambridge, MA.
¹³ Cardiovascular Research Center (K.G.A., P.T.E.), Massachusetts General Hospital, Boston.
¹⁴ Center for Genomic Medicine (K.G.A.), Massachusetts General Hospital, Boston.
¹⁵ British Heart Foundation Research Accelerator (R.T.L.), University College London.
¹⁶ Institute of Health Informatics (R.T.L.), University College London.
¹⁷ Health Data Rsrch UK London (R.T.L.), University College London.
¹⁸ Bart's Heart Center, St. Bartholomew's Hospital, London, United Kingdom (R.T.L.).
¹⁹ Verve Therapeutics (A.V.K.).
²⁰ Division of Cardiology, Brigham and Women's Hospital (A.V.K.).
²¹ Demoulas Center for Cardiac Arrhythmias (S.A.L., P.T.E.), Massachusetts General Hospital, Boston.
²² Department of Pediatrics, Boston Children's Hospital (J.F.).
²³ Department of Pediatrics, Harvard Medical School, Boston, MA (J.F.).

PMID: 37814896
PMCID: PMC10843166
DOI: 10.1161/CIRCGEN.123.004181

No abstract available

Keywords: biomarkers; cardiovascular diseases; database; epigenomics; myocardial infarction; phenotype.

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Conflict of interest statement

Disclosures Dr Lubitz is a full-time employee of Novartis Institutes of BioMedical Research as of July 18, 2022. Dr Lubitz was previously supported by National Institutes of Health (NIH) grants R01HL139731 and R01HL157635, and American Heart Association 18SFRN34250007. Dr Lubitz received sponsored research support from Bristol Myers Squibb, Pfizer, Boehringer Ingelheim, Fitbit, Medtronic, Premier, and IBM and has consulted for Bristol Myers Squibb, Pfizer, Blackstone Life Sciences, and Invitae. Dr Ellinor receives sponsored research support from Bayer AG, IBM Research, Bristol Myers Squibb, and Pfizer; he has also served on advisory boards or consulted for Bayer AG, MyoKardia, and Novartis. Dr Thomas Lumbers receives sponsored research support from Pfizer. Dr Khera is an employee of Verve Therapeutics; has served as a scientific advisor to Amgen, Color Health, Foresite Labs, Illumina, Maze Pharmaceuticals, MedGenome, Navitor Pharmaceuticals, Novartis, Sanofi, Sarepta Therapeutics, Third Rock Therapeutics, and Veritas International; holds equity in Verve Therapeutics, Color Health, and Foresite Labs; and has received research funding from IBM Research. Dr Butterworth reports institutional grants outside of this work from AstraZeneca, Bayer, Biogen, BioMarin, Bioverativ, Novartis, Regeneron, and Sanofi.

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References

1. McClellan M, Brown N, Califf RM, Warner JJ. Call to Action: Urgent Challenges in Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation. 2019;139:e44–e54. - PubMed
1. Costanzo MC, von Grotthuss M, Massung J, Jang D, Caulkins L, Koesterer R, Gilbert C, Welch RP, Kudtarkar P, Hoang Q, et al. The Type 2 Diabetes Knowledge Portal: an open access genetic resource dedicated to type 2 diabetes and related traits. Cell Metabolism. 2023, 35:P695–710.E6. - PMC - PubMed
1. Crawford KM, Gallego-Fabrega C, Kourkoulis C, Miyares L, Marini S, Flannick J, Burtt NP, von Grotthuss M, Alexander B, Costanzo MC, et al. Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke. Stroke. 2018; 49:470–475. - PMC - PubMed
1. Dornbos P, Singh P, Jang D, Mahajan A, Biddinger SB, Rotter JI, McCarthy MI, Flannick J. Evaluating human genetic support for hypothesized metabolic disease genes. Cell Metabolism. 2022;34:661–666. - PMC - PubMed
1. Khomtchouk BB, Nelson CS, Vand KA, Palmisano S, Grossman RL. HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations. Database (Oxford). 2020;baaa115. - PMC - PubMed

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Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research

Affiliations

Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research

Authors

Affiliations

Conflict of interest statement

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Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical