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Comment
. 2023 Dec;15(2):2267185.
doi: 10.1080/19490976.2023.2267185. Epub 2023 Oct 10.

Microbial-host-isozyme: unveiling a new era in microbiome-host interaction

Lei Miao  1 , Herbert Tilg  2 , Ming-Hua Zheng  3   4
Affiliations
Comment

Microbial-host-isozyme: unveiling a new era in microbiome-host interaction

Lei Miao et al. Gut Microbes. 2023 Dec.

Abstract

Wang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota-host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases.

Keywords: Microbial-Host isozymes; metabolic diseases.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Microbial-host-isozyme mining and verification system.
See this image and copyright information in PMC

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