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Randomized Controlled Trial
. 2024 Jan;57(1):2-11.
doi: 10.1111/iej.13986. Epub 2023 Oct 10.

Outcome of single-visit root canal treatment with or without MTAD: A randomized controlled clinical trial

Berkcan Yildiz  1 , Aysin Dumani  1 , Adile Sehnaz Isci  1 , Selen Nihal Sisli  2 , Berkhas Tumani Ustdal  3 , Oguz Yoldas  1
Affiliations
Randomized Controlled Trial

Outcome of single-visit root canal treatment with or without MTAD: A randomized controlled clinical trial

Berkcan Yildiz et al. Int Endod J. 2024 Jan.

Abstract

Aim: This study aimed to investigate 2-year changes in periapical trabecular patterns in single-rooted teeth with apical periodontitis using fractal analysis and periapical index (PAI) after root canal treatment performed with or without BioPure MTAD solution.

Methodology: In this randomized clinical trial, 100 patients were selected and randomized to either the BioPure MTAD or the control groups. Initial periapical radiographs were obtained for each participant before and 2 years after root canal treatment. The region of interest in the periapical lesion around the root apex was selected from the paired periapical radiographs, and then, the fractal dimension (FD) was calculated. With regards to the classification of periapical status, PAI was labelled as "healed" (PAI ≤ 2) or "unhealed" (PAI ≥ 3).

Results: After 24 months, 28 patients did not comply with the follow-up and the data of 72 patients were compared. When the initial and the follow-up PAI scores were compared, the decrease was statistically significant in 33 of 37 teeth (89.2%) and 32 of 35 teeth (91.4%) in the BioPure MTAD and control group, respectively. In both groups, statistically significant increases were observed in FD values after 2 years in all patients (p < .001). No significant difference was found between the two groups amongst decreased PAI scores and increased FD values.

Conclusions: Root canal treatments with or without BioPure MTAD irrigation contributed to periapical healing in single-visit root canal treatment. Two years after root canal treatment, the extent of the periapical trabecular bone radiographically increased, as the FD and PAI data revealed.

Keywords: BioPure MTAD; apical periodontitis; fractal analysis; periapical index; randomized clinical trial; treatment outcome.

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References

REFERENCES

    1. Ballal, N.V., Gandhi, P., Shenoy, P.A., Shenoy Belle, V., Bhat, V., Rechenberg, D.K. et al. (2019) Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double-blind trial. International Endodontic Journal, 52, 1274-1282.
    1. Ballal, N.V., Jain, H., Rao, H., Johnson, A.D., Baeten, J. & Wolcott, J.F. (2019) Evaluation of SmearOFF, maleic acid and two EDTA preparations in smear layer removal from root canal dentin. Acta Odontologica Scandinavica, 77, 28-32.
    1. Ballal, N.V., Narkedamalli, R., Gandhi, P., Arias-Moliz, M.T., Baca, P., Das, S. et al. (2023) Biological and chemical properties of 2-in-1 calcium-chelating and antibacterial root canal irrigants. Journal of Dentistry, 134, 104526.
    1. Boubaris, M., Chan, K.L., Zhao, W., Cameron, A., Sun, J., Love, R. et al. (2021) A volume-based novel cone-beam computed tomographic periapical index. Journal of Endodontics, 47, 1308-1313.
    1. Bürklein, S., Hinschitza, K., Dammaschke, T. & Schäfer, E. (2012) Shaping ability and cleaning effectiveness of two single-file systems in severely curved root canals of extracted teeth: Reciproc and WaveOne versus Mtwo and ProTaper. International Endodontic Journal, 45, 449-461.

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