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. 2023 Oct:72:103219.
doi: 10.1016/j.scr.2023.103219. Epub 2023 Oct 2.

Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA2 variants

Mao Zhang  1 , Wenqiang Liu  1 , Audrey Li  1 , Min H Htet  1 , Rebecca Yu  2 , Melinda L Telli  3 , Joseph C Wu  4
Affiliations

Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA2 variants

Mao Zhang et al. Stem Cell Res. 2023 Oct.

Abstract

Germline pathogenic variants in the BRCA2 gene are strongly correlated with an elevated risk of developing breast cancer. Two specific BRCA2 variants, c.8167G>C (p.Asp2723His) and c.1583del (p.Asn528fs), have been identified from individuals with a family history of breast cancer. Here we generated two iPSC lines from breast cancer patients who are heterozygous carriers of these two variants. These iPSCs exhibit pluripotency and demonstrate the capability to differentiate into three germ layers. These iPSC lines represent a valuable resource for personalized pre-clinical research, offering new opportunities to explore the underlying mechanisms of breast cancer and develop targeted therapeutic approaches.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J.C.W. is a co-founder of Greenstone Biosciences. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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