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. 2023 Oct 17;18(20):e202300464.
doi: 10.1002/cmdc.202300464. Epub 2023 Oct 10.

The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders

Alessio Ciulli  1 , Suzanne O'Connor  1 , Chun-Wa Chung  2 , Ingo V Hartung  3 , Andrea Testa  4 , Danette L Daniels  5 , Laura H Heitman  6
Affiliations

The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders

Alessio Ciulli et al. ChemMedChem. .

Abstract

The 17th EFMC Short Course on Medicinal Chemistry took place April 23-26, 2023 in Oegstgeest, near Leiden in the Netherlands. It covered for the first time the exciting topic of Targeted Protein Degradation (full title: Small Molecule Protein Degraders: A New Opportunity for Drug Design and Development). The course was oversubscribed, with 35 attendees and 6 instructors mainly from Europe but also from the US and South Africa, and representing both industry and academia. This report summarizes the successful event, key lectures given and topics discussed.

Keywords: PROTACs; drug design; medicinal chemistry; molecular glues; protein degraders.

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References

    1. None
    1. K. Li, C. M. Crews, Chem. Soc. Rev. 2022, 51, 5214-5236;
    1. A. Ciulli, N. Trainor, Biochem (Lond) 2021, 43, 74-79.
    1. None
    1. T. Ishida, A. Ciulli, SLAS Discov. 2021, 26, 484-502;

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