Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Oct 10:e1822.
doi: 10.1002/wrna.1822. Online ahead of print.

Cancer-derived non-coding RNAs endow tumor microenvironment with immunosuppressive properties

Tong Hu  1 , Run Shi  1 , Yunru Gu  1 , Hanyu Zhou  1   2 , Yuan Fang  1 , Tingting Xu  1   2 , Yangyue Xu  1 , Xi Wu  1 , Ling Ma  1   2 , Yongqian Shu  1   2
Affiliations
Review

Cancer-derived non-coding RNAs endow tumor microenvironment with immunosuppressive properties

Tong Hu et al. Wiley Interdiscip Rev RNA. .

Abstract

Non-coding RNAs (ncRNAs) have attracted extensive attention due to their vital roles in tumorigenesis and progression, especially in the immunotherapy resistance. Tumor immunotherapy resistance is a crucial factor hindering the efficacy of tumor treatments, which can be largely attributed to the immunosuppressive properties of tumor microenvironment. Current studies have revealed that cancer-derived ncRNAs are involved in the formation of tumor immunosuppressive microenvironment (TIME) through multiple ways. They not only promote the expression of immune checkpoint ligands (e.g., PD-L1, CD47, Gal-9, and CD276) on cancer cell surfaces, but also enhance the secretion of immunosuppressive cytokines (e.g., TGF-β, IL-6, IL-10, VEGF, and chemokines). Cancer-derived ncRNAs could also be transferred into surrounding immune-related cells through extracellular vesicles, thereby inhibiting the cytotoxicity of CD8+ T cells and NK cells, restraining the DC-mediated antigen presentation, inducing the immunosuppressive phenotype transformation of TAMs and CAFs, and enhancing the immunosuppressive functions of Tregs and MDSCs. Herein, we summarize the roles of cancer-derived ncRNAs in regulating TIME formation and further explore their potential applications as prognostic biomarkers and immunotherapeutic targets, which will help us to address the TIME-mediated immunotherapy resistance in the future. This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs.

Keywords: circRNA; immunotherapy; lncRNA; miRNA; tumor immunosuppressive microenvironment.

PubMed Disclaimer

References

REFERENCES

    1. Antonioli, L., Pacher, P., Vizi, E. S., & Haskó, G. (2013). CD39 and CD73 in immunity and inflammation. Trends in Molecular Medicine, 19(6), 355-367. https://doi.org/10.1016/j.molmed.2013.03.005
    1. Ashrafizadeh, M., Zarrabi, A., Orouei, S., Zarrin, V., Rahmani Moghadam, E., Zabolian, A., Mohammadi, S., Hushmandi, K., Gharehaghajlou, Y., Makvandi, P., Najafi, M., & Mohammadinejad, R. (2020). STAT3 pathway in gastric cancer: Signaling, therapeutic targeting and future prospects. Biology, 9(6), 126. https://doi.org/10.3390/biology9060126
    1. Asmamaw, M. D., Shi, X.-J., Zhang, L.-R., & Liu, H.-M. (2022). A comprehensive review of SHP2 and its role in cancer. Cellular Oncology (Dordrecht), 45(5), 729-753. https://doi.org/10.1007/s13402-022-00698-1
    1. Bailly, C., Thuru, X., & Quesnel, B. (2021). Modulation of the Gal-9/TIM-3 immune checkpoint with α-lactose. Does anomery of lactose matter? Cancers, 13(24), 6365. https://doi.org/10.3390/cancers13246365
    1. Batlle, E., & Massagué, J. (2019). Transforming growth factor-β signaling in immunity and cancer. Immunity, 50(4), 924-940. https://doi.org/10.1016/j.immuni.2019.03.024

LinkOut - more resources