Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;35(6):741-752.
doi: 10.1016/j.sdentj.2023.05.018. Epub 2023 Jun 7.

Nanohydroxyapatite in dentistry: A comprehensive review

C Pushpalatha  1 , V S Gayathri  1 , S V Sowmya  2 , Dominic Augustine  2 , Ahmed Alamoudi  3 , Bassam Zidane  4 , Nassreen Hassan Mohammad Albar  5 , Shilpa Bhandi  6
Affiliations

Nanohydroxyapatite in dentistry: A comprehensive review

C Pushpalatha et al. Saudi Dent J. 2023 Sep.

Abstract

Enamel, being the hardest and the highest mineralized tissue of the human body, contains nearly 96% inorganic components and 4% organic compounds and water. Dentin contains 65% inorganic components and 35% organic and water content. The translucency and white appearance of enamel are attributed to Hydroxyapatite (HA), which constitutes the major part of the inorganic component of dental hard tissue. With the advent of nanotechnology, the application of Nanohydroxyapatite (nHA) has piqued interest in dentistry due to its excellent mechanical, physical, and chemical properties. Compared to HA, nHA is found to have superior properties such as increased solubility, high surface energy and better biocompatibility. This is due to the morphological and structural similarity of nanosized hydroxyapatite particles to tooth hydroxyapatite crystals. These nanoparticles have been incorporated into various dental formulations for different applications to ensure comprehensive oral healthcare. To prevent dental caries, several nHA based dentifrices, mouth rinsing solutions and remineralizing pastes have been developed. nHA-based materials, such as nanocomposites, nano impression materials, and nanoceramics, have proven to be very effective in restoring tooth deformities (decay, fracture, and tooth loss). The nHA coating on the surface of the dental implant helps it bind to the bone by forming a biomimetic coating. A recent innovative strategy involves using nHA to reduce dentinal hypersensitivity and to reconstruct periodontal bone defects. The purpose of the present review is to discuss the different applications of nHA in dentistry, especially in preventive and restorative dentistry, dental implantology, bleaching and dentine hypersensitivity management.

Keywords: Bleaching; Dental Implantology; Dental caries; Hydroxyapatite; Nanohydroxyapatite; Nanoparticles; Remineralization.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Various Dental Applications of Nanohydroxyapatite.
Fig. 2
Fig. 2
Mechanism of Action of Nanohydroxyapatite (nHAP) on Initial Enamel Caries.
See this image and copyright information in PMC

References

    1. Abdulkareem E.H., Memarzadeh K., Allaker R.P., Huang J., Pratten J., Spratt D. Anti-biofilm activity of zinc oxide and hydroxyapatite nanoparticles as dental implant coating materials. J. Dent. 2015 Dec;43(12):1462–1469. - PubMed
    1. Abidi S.S.A., Murtaza Q. Synthesis and characterization of nano-hydroxyapatite powder using wet chemical precipitation reaction. J. Mater. Sci. Technol. 2014 Apr;30(4):307–310.
    1. Ahmadzadeh H., Isfahani T., Kharazi A.Z. Modified mechanical coating technique for the preparation of Nanohydroxyapatite coated Ti–6Al–4V dental implants. Prot. Met. Phys. Chem. 2020;56(4):766–771.
    1. Al-Ahmady HH, Abd Elazeem AF, Bellah Ahmed NE moataz, Shawkat WM, Elmasry M, Abdelrahman MA, et al. Combining autologous bone marrow mononuclear cells seeded on collagen sponge with Nano Hydroxyapatite, and platelet-rich fibrin: Reporting a novel strategy for alveolar cleft bone regeneration. Journal of Cranio-Maxillofacial Surgery. 2018 Sep;46(9):1593–600.8. - PubMed
    1. Alatawi R.A.S., Elsayed N.H., Mohamed W.S. Influence of hydroxyapatite nanoparticles on the properties of glass ionomer cement. J. Mater. Res. Technol. 2019 Jan;8(1):344–349.

LinkOut - more resources