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Review
. 2023 Sep 15;13(9):3854-3863.
eCollection 2023.

The association between birth weight and the risk of neuroblastoma: a meta-analysis of observational studies involving 4,361,141 participants

Hatice Nur Olgun  1 , Mehmet Emin Arayici  2 , Refik Emre Cecen  3 , Yasemin Basbinar  4 , Hulya Ellidokuz  3   5
Affiliations
Review

The association between birth weight and the risk of neuroblastoma: a meta-analysis of observational studies involving 4,361,141 participants

Hatice Nur Olgun et al. Am J Cancer Res. .

Abstract

One of the most common extracranial solid tumors in childhood is neuroblastoma. In this study, it was aimed to perform a systematic review and meta-analysis to evaluate the risk of neuroblastoma in both high and low birth weights. The PRISMA and MOOSE guidelines were followed during the design, analysis, and reporting of this study. A comprehensive literature search was undertaken for the published papers in Embase, PubMed/Medline, Scopus, and the Web of Science (WoS) databases. The odds ratio (OR) of neuroblastoma in high and low birth weight groups, with 95% confidence intervals (CIs), were calculated using the random-effects and fixed-effects models. A total of 16 papers and 4,361,141 participants were included in this study. When the random-effects model and the fixed-effects model were used, high birth weight was associated with an increased risk of neuroblastoma (OR = 1.17; 95% CI: 1.06-1.29, P = 0.002; heterogeneity: Chi2 = 2.33, df = 15, I2 = 0%, P>0.05). Similarly, it was observed that individuals with low birth weights may also face an increased risk of developing neuroblastoma later in life (OR = 1.19; 95% CI: 1.03-1.37, P = 0.017; heterogeneity: Chi2 = 16.93, df = 15, I2 = 0%, P = 0.323). In conclusion, both high and low birth weight in individuals may be among the important risk factors for neuroblastoma development.

Keywords: Neuroblastoma; birth weight; meta-analysis.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
PRISMA flow diagram showing to study selection process.
Figure 2
Figure 2
ORs for neuroblastoma in participants with high birth weight (>4000).
Figure 3
Figure 3
Sensivity analysis for neuroblastoma in participants with high birth weight (>4000).
Figure 4
Figure 4
ORs for neuroblastoma in participants with low birth weight (<2500).
Figure 5
Figure 5
Sensivity analysis for neuroblastoma in participants with low birth weight (<2500).
See this image and copyright information in PMC

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