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. 2023 Dec;1530(1):138-151.
doi: 10.1111/nyas.15073. Epub 2023 Oct 11.

Role of the rostral dorsomedial column of the periaqueductal gray during social defeat in rats

Alisson Pinto de Almeida  1 , Alicia Moraes Tamais  1 , Carolina Zerbini  1 , Fernando Falkenburger Melleu  1 , Newton Sabino Canteras  1 , Simone Cristina Motta  1
Affiliations

Role of the rostral dorsomedial column of the periaqueductal gray during social defeat in rats

Alisson Pinto de Almeida et al. Ann N Y Acad Sci. 2023 Dec.

Abstract

Previous studies showed that the dorsal premammillary nucleus of the hypothalamus (PMD) is involved in social passive defensive behaviors likely to be meditated by descending projections to the periaqueductal gray (PAG). We focused on the rostral dorsomedial PAG (rPAGdm) to reveal its putative neural mechanisms involved in mediating social defensive responses. By combining retrograde tracing and FOS expression analysis, we showed that in addition to the PMD, the rPAGdm is influenced by several brain sites active during social defeat. Next, we found that cytotoxic lesions of the rPAGdm drastically reduced passive defense and did not affect active defensive responses. We then examined the rPAGdm's projection pattern and found that the PAGdm projections are mostly restricted to midbrain sites, including the precommissural nucleus, different columns of the PAG, and the cuneiform nucleus (CUN). Also, we found decreased FOS expression in the caudal PAGdm, CUN, and PMD after the rPAGdm was lesioned. The results support that the rPAGdm mediates passive social defensive responses through ascending paths to prosencephalic circuits likely mediated by the CUN. This study provides further support for the role of the PAG in the modulation of behavioral responses by working as a unique hub for influencing prosencephalic sites during the mediation of aversive responses.

Keywords: defensive behavior; hypothalamus; mesencephalon; social fear; social stress.

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References

REFERENCES

    1. Krishnan, V., Han, M.-H. u, Graham, D. L., Berton, O., Renthal, W., Russo, S. J., Laplant, Q., Graham, A., Lutter, M., Lagace, D. C., Ghose, S., Reister, R., Tannous, P., Green, T. A., Neve, R. L., Chakravarty, S., Kumar, A., Eisch, A. J., Self, D. W., … Nestler, E. J. (2007). Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell, 131, 391-404.1.
    1. Norman, K. J., Seiden, J. A., Klickstein, J. A., Han, X., Hwa, L. S., Debold, J. F., & Miczek, K. A. (2015). Social stress and escalated drug self-administration in mice I. Alcohol and corticosterone. Psychopharmacology, 232, 991-1001.
    1. Russo, S. J., & Nestler, E. J. (2013). The brain reward circuitry in mood disorders. Nature Reviews Neuroscience, 14, 609-625.
    1. Der-Avakian, A., Mazei-Robison, M. S., Kesby, J. P., Nestler, E. J., & Markou, A. (2014). Enduring deficits in brain reward function after chronic social defeat in rats: Susceptibility, resilience, and antidepressant response. Biological Psychiatry, 76, 542-549.
    1. Motta, S. C., Goto, M., Gouveia, F. V., Baldo, M. V. C., Canteras, N. S., & Swanson, L. W. (2009). Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders. Proceedings of the National Academy of Sciences of the United States of America, 106, 4870-4875.

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