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. 2023 Oct 20;88(20):14736-14747.
doi: 10.1021/acs.joc.3c01901. Epub 2023 Oct 11.

Access to Fully Substituted Dihydroindazoles Via Hexadehydro-Diels-Alder/[3 + 2] Cycloaddition

Weigang Xu  1 , Xiuhuan Li  2 , Luyao Zou  1 , Xiaoli Li  1 , Zhiqiang Zhang  1 , Sajjad Ali  1 , Zhengshen Wang  1 , Pengfei Li  1 , Huaiji Zheng  1
Affiliations

Access to Fully Substituted Dihydroindazoles Via Hexadehydro-Diels-Alder/[3 + 2] Cycloaddition

Weigang Xu et al. J Org Chem. .

Abstract

A cascade hexadehydro-Diels-Alder (HDDA)/[3 + 2] cycloaddition reaction between tetrayne and N,N'-cyclic acylhydrazone is described. This strategy allows the efficient construction of fully substituted 2,3-dihydro-1H-indazole scaffolds which have insecticidal activity against the third instar larvae of Mythimna separata.

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