Strength in diversity: Widening B cell recruitment for broader vaccine protection
- PMID: 37820580
- DOI: 10.1016/j.immuni.2023.09.009
Strength in diversity: Widening B cell recruitment for broader vaccine protection
Abstract
Generating potent neutralizing antibodies is a unifying goal of next-generation vaccines. In this issue of Immunity, Ols et al. show that multivalent nanoparticle vaccines displaying RSV F protein can enable recruitment of more diverse B cell specificities into the vaccine response, resulting in increased potency and breadth of antibody immunity to both RSV and the related human metapneumovirus.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.Immunity. 2023 Oct 10;56(10):2425-2441.e14. doi: 10.1016/j.immuni.2023.08.011. Epub 2023 Sep 8. Immunity. 2023. PMID: 37689061
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