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. 2023 Oct 17;82(16):1583-1594.
doi: 10.1016/j.jacc.2023.08.015.

10-Year Cardiovascular Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus

Christine Gyldenkerne  1 , Martin Bødtker Mortensen  2 , Johnny Kahlert  3 , Pernille Gro Thrane  4 , Kevin Kris Warnakula Olesen  4 , Henrik Toft Sørensen  3 , Reimar Wernich Thomsen  3 , Michael Maeng  5
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Free article

10-Year Cardiovascular Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus

Christine Gyldenkerne et al. J Am Coll Cardiol. .
Free article

Abstract

Background: Contemporary data on cardiovascular disease (CVD) risk in patients with newly diagnosed type 2 diabetes mellitus (T2DM) is needed to guide appropriate preventive management.

Objectives: The authors sought to investigate sex- and age-specific 10-year CVD risk in patients with newly diagnosed T2DM compared with the general population.

Methods: A cohort study was conducted of all Danish patients with T2DM diagnosed between 2006 and 2013 (n = 142,587) and sex- and age-matched individuals from the general population (n = 388,410), all without prior atherosclerotic CVD. Ten-year CVD risk (myocardial infarction, stroke, and fatal CVD) was estimated.

Results: A total of 52,471 CVD events were recorded. Compared with the general population, the 10-year CVD risks were higher in patients with T2DM in both sexes and across all age groups, especially among younger individuals. For example, patients aged 40 to 49 years had the largest 10-year CVD risk difference (T2DM 6.1% vs general population 3.3%; risk difference: 2.8%, subdistribution HR: 1.91; 95% CI: 1.76-2.07). The age when a given CVD risk was reached differed substantially between the cohorts. Thus, a 10-year CVD risk of 5% was reached at age 43 in men with T2DM compared with 12 years later, at age 55, in men without T2DM. A 10-year CVD risk of 5% was reached at age 51 in women with T2DM and 10 years later, at age 61, in women without T2DM.

Conclusions: Newly diagnosed T2DM increased 10-year CVD risk across both sexes and all age groups, especially among younger patients, with CVD occurring ≤12 years earlier than in general population individuals.

Keywords: cardiovascular disease; cohort study; epidemiology; primary prevention; type 2 diabetes mellitus.

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Conflict of interest statement

Funding Support and Author Disclosures This research was funded by the Department of Cardiology, Aarhus University Hospital, Denmark. The funders had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. The Department of Clinical Epidemiology, Aarhus University Hospital, receives funding for other studies from companies in the form of research grants to (and administered by) Aarhus University. None of these studies have any relation to the current study. Dr Maeng is supported by a grant from the Novo Nordisk Foundation (grant number NNF22OC0074083); and has received lecture and advisory board fees from Novo Nordisk, Denmark. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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