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. 2023 Oct 11;13(1):17235.
doi: 10.1038/s41598-023-43287-4.

Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Paulius Jonaitis  1 , Olga P Nyssen  2 , Ilaria Maria Saracino  3 , Giulia Fiorini  3 , Dino Vaira  3 , Ángeles Pérez-Aísa  4 , Bojan Tepes  5 , Manuel Castro-Fernandez  6 , Manuel Pabón-Carrasco  6 , Alma Keco-Huerga  6 , Irina Voynovan  7 , Alfredo J Lucendo  8 , Ángel Lanas  9 , Samuel J Martínez-Domínguez  9 , Enrique Alfaro Almajano  9 , Luis Rodrigo  10 , Ludmila Vologzanina  11 , Natasa Brglez Jurecic  12 , Maja Denkovski  12 , Luis Bujanda  13 , Umud Mahmudov  14 , Mārcis Leja  15 , Frode Lerang  16 , Gülüstan Babayeva  17 , Dmitry S Bordin  7   18   19 , Antonio Gasbarrini  20 , Juozas Kupcinskas  1 , Oleksiy Gridnyev  21 , Theodore Rokkas  22 , Ricardo Marcos-Pinto  23 , Perminder S Phull  24 , Sinead M Smith  25 , Ante Tonkić  26 , Doron Boltin  27 , György Miklós Buzás  28 , Štěpán Šembera  29 , Halis Şimşek  30 , Tamara Matysiak-Budnik  31 , Vladimir Milivojevic  32 , Wojciech Marlicz  33 , Marino Venerito  34 , Lyudmila Boyanova  35 , Michael Doulberis  36 , Lisette G Capelle  37 , Anna Cano-Català  38 , Leticia Moreira  39 , Francis Mégraud  40 , Colm O'Morain  25 , Javier P Gisbert #  41 , Laimas Jonaitis #  1 ; Hp-EuReg investigators
Collaborators, Affiliations

Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Paulius Jonaitis et al. Sci Rep. .

Erratum in

  • Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations.
    Jonaitis P, Nyssen OP, Saracino IM, Fiorini G, Vaira D, Pérez-Aísa Á, Tepes B, Castro-Fernandez M, Pabón-Carrasco M, Keco-Huerga A, Voynovan I, Lucendo AJ, Lanas Á, Martínez-Domínguez SJ, Almajano EA, Rodrigo L, Vologzanina L, Brglez Jurecic N, Denkovski M, Bujanda L, Mahmudov U, Leja M, Lerang F, Babayeva G, Bordin DS, Gasbarrini A, Kupcinskas J, Gridnyev O, Rokkas T, Marcos-Pinto R, Phull PS, Smith SM, Tonkić A, Boltin D, Buzás GM, Šembera Š, Şimşek H, Matysiak-Budnik T, Milivojevic V, Marlicz W, Venerito M, Boyanova L, Doulberis M, Capelle LG, Cano-Català A, Moreira L, Mégraud F, O'Morain C, Gisbert JP, Jonaitis L; Hp-EuReg investigators. Jonaitis P, et al. Sci Rep. 2023 Nov 1;13(1):18821. doi: 10.1038/s41598-023-45888-5. Sci Rep. 2023. PMID: 37914853 Free PMC article. No abstract available.

Abstract

The prevalence of Helicobacter pylori remains high in the older population. Specific age-related peculiarities may impact the outcomes of H. pylori treatment. The aim of the study was to evaluate the diagnostics and effectiveness of H. pylori eradication between the younger and older European populations. "European Registry on H. pylori Management (Hp-EuReg)" data from 2013 to 2022 were analyzed. Patients were divided into older (≥ 60 years) and younger (18-59 years) groups. Modified intention-to-treat (mITT) and per-protocol (PP) analysis was performed. 49,461 patients included of which 14,467 (29%) were older-aged. Concomitant medications and penicillin allergy were more frequent among the older patients. Differences between younger and older populations were observed in treatment duration in first-line treatment and in proton pump inhibitors (PPIs) doses in second-line treatment. The overall incidence of adverse events was lower in the older adults group. The overall first-line treatment mITT effectiveness was 88% in younger and 90% in the older patients (p < 0.05). The overall second-line mITT treatment effectiveness was 84% in both groups. The effectiveness of the most frequent first- and second-line triple therapies was suboptimal (< 90%) in both groups. Optimal efficacy (≥ 90%) was achieved by using bismuth and non-bismuth-based quadruple therapies. In conclusion, the approach to the diagnostics and treatment of H. pylori infection did not generally differ between younger and older patients. Main differences were reported in the concurrent medications, allergy to penicillin and adverse events both in first- and second-line treatment. Optimal effectiveness rates were mostly achieved by using bismuth and non-bismuth-based quadruple therapies. No clinically relevant differences in the effectiveness between the age groups were observed.

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Conflict of interest statement

Prof. J. Gisbert has served as speaker, consultant, and advisory member for or has received research funding from Mayoly, Allergan, Diasorin, Gebro Pharma, and Richen. Dr. Nyssen has received research funding from Mayoly and Allergan. The remaining authors have declared no conflict of interest.

Figures

Figure 1
Figure 1
Study flow chart. PP per-protocol, mITT modified Intention-to-treat.
Figure 2
Figure 2
Comparison of the mITT effectiveness of 6 most frequent first-line prescriptions between the younger and older adults.
Figure 3
Figure 3
Comparison of the mITT effectiveness of six most frequent second-line prescriptions between the younger and older adults.
See this image and copyright information in PMC

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