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Multicenter Study
. 2023 Oct 11;15(1):169.
doi: 10.1186/s13195-023-01305-7.

Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?

Clément Aveneau  1   2 , David Wallon  3 , Bertrand Degos  4 , Alexandre Obadia  5 , Claire Hourregue  1 , Sarah Benisty  5 , Béatrice Garcin  4 , Julien Dumurgier  1 , Claire Paquet  6   7
Affiliations
Multicenter Study

Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?

Clément Aveneau et al. Alzheimers Res Ther. .

Abstract

Introduction: The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood.

Methods: Multicenter retrospective study in 4 French expert neurological centers. Patients were categorized in 3 groups according to their first more predominant symptoms: cognitive, psychiatric, or motor.

Results: Analysis of 310 DLB patients. The mean age was 73.5 years old (SD 7.5) including 32.3% of women. The mean follow-up was 7.25 years (SD 3.6). We observed that the full clinical picture was more frequent in the motor group than in the cognitive group (p = 0.01); male gender and age at onset were associated with a significant excess risk of instantaneous mortality (p = 0.01).

Conclusion: Initial symptoms may affect the clinical course of patients, but no significant difference in mortality was observed.

Keywords: Clinical subtypes; Dementia with Lewy body; Onset; Prodromal; Prognosis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Kaplan–Meier survival curve (death) according to clinical entry points. Survival curve according to the Kaplan–Meier method for patients with motor (blue line), cognitive (red line), or psychiatric (green line) predominant clinical onset. The numbers below the curve indicate the number of patients at risk at each time point. Differences between the two groups were evaluated using a log-rank test (p = 0.11). Data were censored at the date of last observation (crosses) or death
See this image and copyright information in PMC

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