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. 2023 Jul-Aug;68(4):490.
doi: 10.4103/ijd.ijd_910_22.

Vegetative Skin Lesions in Patient with Bruton's Agammaglobulinemia

Cristian Fidanzi  1 , Flavia Manzo Margiotta  1 , Matteo Bevilacqua  1 , Valerio Ortenzi  2 , Valerio Rocchi  3 , Giammarco Granieri  1 , Marco Romanelli  1 , Elisabetta Manni  1
Affiliations

Vegetative Skin Lesions in Patient with Bruton's Agammaglobulinemia

Cristian Fidanzi et al. Indian J Dermatol. 2023 Jul-Aug.
No abstract available

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a-c) Clinical appearance of skin lesions. (d-f) Healing of skin lesions at 3-month follow-up
Figure 2
Figure 2
Skin shows an ulcerated area associated with an underlying abscess collection, rich in necrotic material admixed with microorganisms. Epidermis is acanthotic, parakeratotic and shows reactive dyskeratosis as well as neutrophilic exocytosis. Dermal papillae are edematous and congested. There is a widespread inflammatory T-lymphoid infiltrate both in the papillary and superficial reticular dermis. Absence of B lymphocytes is consistent with the clinical picture of Bruton's agammaglobulinemia. (Hematoxylin and eosin, 5x magnification)
Figure 3
Figure 3
On the inside of abscessed area, clusters of microorganisms (*) display a rounded shape, and they appear surrounded by a dense fibro-collagenic eosinophilic tissue rim (►), which separates and isolates them from the surrounding neutrophilic and lymphocytic inflammatory reaction. Interestingly, the microorganisms appear to be arranged in tetrads; this arrangement is described in the literature as classic for Micrococcus and Sarcina species, but in culture such bacteria have not been isolated. (Hematoxylin and eosin, 40x magnification)
See this image and copyright information in PMC

References

    1. Suri D, Rawat A, Singh S. X-linked agammaglobulinemia. Indian J Pediatr. 2016;83:331–7. doi: 10.1007/s12098-015-2024-8. - PubMed
    1. Devi B, Behera B, Dash MI, Puhan M, Pattnaik SS, Patro S. Botryomycosis. Indian J Dermatol. 2013;58:406. doi: 10.4103/0019-5154.117322. - PMC - PubMed
    1. Padilla-Desgarennes C, Vázquez-González D, Bonifaz A. Botryomycosis. Clin Dermatol. 2012;30:397–402. doi: 10.1016/j.clindermatol. 2011.09.010. - PubMed
    1. Harman RR, English MP, Halford M, Saihan EM, Greenham LW. Botryomycosis: A complication of extensive follicular mucinosis. Br J Dermatol. 1980;102:215–22. - PubMed
    1. Neafie RC, Marty AM. Unusual infections in humans. Clin Microbiol Rev. 1993;6:34–56. doi: 10.1128/CMR.6.1.34. - PMC - PubMed