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Review
. 2023 Oct 9:16:17562848231195680.
doi: 10.1177/17562848231195680. eCollection 2023.

Clinical utility of colon capsule endoscopy: a moving target?

Gohar Jalayeri Nia  1 , Ramesh P Arasaradnam  2   3   4   5 , Anastasios Koulaouzidis  6   7   8   9
Affiliations
Review

Clinical utility of colon capsule endoscopy: a moving target?

Gohar Jalayeri Nia et al. Therap Adv Gastroenterol. .

Abstract

The purpose of this article is to provide an overview of white light colon capsule endoscopy's current clinical application, concentrating on its most recent developments. Second-generation colon capsule endoscopy (CCE2) is approved by the FDA for use as an adjunctive test in patients with incomplete colonoscopy and within Europe in patients at average risk, those with incomplete colonoscopies or those unwilling to undergo conventional colonoscopies. Since the publication of European Society of GI Endoscopy guidelines on the use of CCE, there has been a significant increase in comparative studies on the diagnostic yield of CCE. This paper discusses CCE2 in further detail. It explains newly developed colon capsule system and the current status on the use of CCE, it also provides a comprehensive summary of systematic reviews on the implementation of CCE in colorectal cancer screening from a methodological perspective. Patients with ulcerative colitis can benefit from CCE2 in terms of assessing mucosal inflammation. As part of this review, performance of CCE2 for assessing disease severity in ulcerative colitis is compared with colonoscopy. Finally, an assessment if CCE can become a cost-effective clinical service overall.

Keywords: CT colonography; bowel preparation; colon capsule endoscopy; colorectal cancer; completion rate; inflammatory bowel disease; ulcerative colitis.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
CCE equipment (https://www.medtronic.com/covidien/en-us/products/capsule-endoscopy/pillcam-colon-2-system.html).
Figure 2.
Figure 2.
(a, b) Taken with OMOM CC100, Jinshan Science & TechnologyLtd, Yubei, China.
Figure 3.
Figure 3.
influential factors associated with longer CCE transit times and lower completion rates. CCE, colon capsule endoscopy.
Figure 4.
Figure 4.
The layer cake theory.
See this image and copyright information in PMC

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