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Review
. 2023 Sep 26:14:1271051.
doi: 10.3389/fimmu.2023.1271051. eCollection 2023.

The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

Meichao Cai  1 , Dongsheng Zhao  1 , Xiao Han  1 , Shuang Han  2 , Wenxin Zhang  1 , Zhennan Zang  1 , Chenchen Gai  1 , Rong Rong  1 , Tian Gao  1
Affiliations
Review

The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

Meichao Cai et al. Front Immunol. .

Abstract

Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The secretion of inflammatory factors and oxidative products by the vessel wall in the diseased segment has the ability to influence the phenotype of perivascular adipocytes. Additionally, the secretion of adipokines by perivascular adipose tissue exacerbates the inflammatory response in the diseased vessel wall. Therefore, quantitative and qualitative studies of perivascular adipose tissue are of great value in the context of vascular inflammation and may provide a reference for the assessment of cardiovascular ischemic disease.

Keywords: adipocytokines (adipokines); brown adipose tissue (BAT); cardiovascular disease; perivascular adipose tissue (PVAT); white adipose tissue (WAT).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Perivascular adipose tissue. Schematic diagram of the composition of PVAT.
Figure 2
Figure 2
The adipokines of perivascular adipose tissueadipokines. PVAT is a complex adipose tissue composed of a variety of adipocytes, including white-brown adipocytes, beige adipocytes, and brown adipocytes, PVAT secretes pro-inflammatory and anti-inflammatory adipokines into the vasculature.
See this image and copyright information in PMC

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