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Comment
. 2023 Nov 2;146(11):4411-4413.
doi: 10.1093/brain/awad354.

Out of one, how many? Subtyping in epilepsy

Erik Kaestner  1 , Anny Reyes  1
Affiliations
Comment

Out of one, how many? Subtyping in epilepsy

Erik Kaestner et al. Brain. .

Abstract

This scientific commentary refers to ‘Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference’ by Xiao et al. (https://doi.org/10.1093/brain/awad284).

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Conflict of interest statement

The authors report no competing interests.

Figures

Figure 1
Figure 1
Approaches to subtyping in epilepsy. The top half of the figure (Clinical Classifications) illustrates the patients included by Xiao et al., divided into focal epilepsy and idiopathic generalized epilepsy (IGE) subtypes. These subtypes are well established in the epilepsy field, with judgements made by clinical team consensus. The bottom half of the figure represents the reclassification of these patients using the subtype and stage inference (SuStaIn) approach using T1-weighted structural imaging from each patient. Focal and IGE patients were pooled into SuStaIn separately, with three resulting subtypes identified. Two were common across focal epilepsy and IGE (cortex subtype and basal ganglia subtype) while one was unique to focal epilepsy (hippocampus subtype).
See this image and copyright information in PMC

Comment on

References

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