doi: 10.1016/s0378-4347(00)83503-3.
Quantitative alterations in the metabolism of carbonyl compounds due to diet-induced lipid peroxidation in rats
- PMID: 3782414
- DOI: 10.1016/s0378-4347(00)83503-3
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Quantitative alterations in the metabolism of carbonyl compounds due to diet-induced lipid peroxidation in rats
J Chromatogr.
.
Abstract
Following the dietary induction of lipid peroxidation in rats (verified by the levels of malonaldehyde and glutathione peroxidase), the urinary carbonyl compounds were followed chromatographically. Through a headspace gas chromatographic procedure, increases of several aldehydes and furan derivatives were noticed. Liquid chromatography of the dinitrophenylhydrazone derivatives of urinary carbonyls provided a more definitive experiment, in which the increased-peroxidation animals could be compared to those maintained on a control diet. Several carbonyl metabolites, identified by mass spectrometry, were elevated following the lipid peroxidation induction.
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