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. 2023 Oct 11;10(10):e01174.
doi: 10.14309/crj.0000000000001174. eCollection 2023 Oct.

Comment on Fomepizole and Acetaminophen Overdose

Kim-Long R Nguyen  1 , Michael E Mullins  1
Affiliations

Comment on Fomepizole and Acetaminophen Overdose

Kim-Long R Nguyen et al. ACG Case Rep J. .
No abstract available

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Figures

Figure 1.
Figure 1.
Serial acetaminophen concentrations in 6 patients treated with IV N-acetylcysteine and IV fomepizole from Reference 5 (available as open access under Creative Commons CC BY license).
See this image and copyright information in PMC

References

    1. Haider MA, Gheit YS, Nagi T, et al. . Severe acetaminophen toxicity from the use of oxycodone-acetaminophen with normal liver function tests and a completely asymptomatic course of hospitalization. ACG Case Rep J . 2023;10:e01126. - PMC - PubMed
    1. Prescott LF. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med. 1981;141(3):386–9. - PubMed
    1. Kang AM, Padilla-Jones A, Fisher ES, et al. . The effect of 4-methylpyrazole on oxidative metabolism of acetaminophen in human volunteers. J Med Toxicol. 2020;16(2):169–76. - PMC - PubMed
    1. Rampon G, Wartman H, Osmon S, Scalzo A. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: A case series. Toxicol Commun. 2020;4(1):1–4.
    1. Filip AB, Mullins ME. Fomepizole should be used more liberally in paracetamol overdose. Br J Clin Pharmacol. 2023;89(2):594–8. - PubMed

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