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Comparative Study
. 1986 Dec 1;164(6):2083-8.
doi: 10.1084/jem.164.6.2083.

Gene correction in the evolution of the T cell receptor beta chain

E Jouvin-Marche, M Heller, S Rudikoff
Comparative Study

Gene correction in the evolution of the T cell receptor beta chain

E Jouvin-Marche et al. J Exp Med. .

Abstract

Mutational mechanisms operating at the T cell receptor beta chain locus have been examined by comparison of the CT beta 1 and CT beta 2 gene sequences from Mus pahari, believed to be the oldest living species in the genus Mus, with those of inbred mice. Results indicate that a gene correction event independent of that suggested to have occurred in inbred mice has homogenized the M. pahari CT beta exon 1 sequences, minimizing diversity in this region of the molecule. These observations suggest that correction events such as gene conversion may occur frequently, even in pauci-gene families with as few as two members, and therefore play a significant role in gene diversification or homogenization of small as well as large gene families.

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