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. 2023 Dec;165(12):4183-4189.
doi: 10.1007/s00701-023-05827-9. Epub 2023 Oct 13.

Surgery in octogenarians with intracranial meningiomas improves functional outcome at 1 year

Aristotelis S Filippidis  1 , Katharine R Phillips  1 , Victor Lopez-Rivera  2 , Alejandro Enriquez-Marulanda  1 , Charles E Mackel  1 , Ron L Alterman  1 , Rafael A Vega  3
Affiliations

Surgery in octogenarians with intracranial meningiomas improves functional outcome at 1 year

Aristotelis S Filippidis et al. Acta Neurochir (Wien). 2023 Dec.

Abstract

Purpose: The population is aging, and age remains an important factor in deciding surgical candidacy for intracranial tumors. The natural history and surgical behavior of meningiomas in octogenarians are not well understood. We evaluated the surgical and functional outcomes, including survival, among octogenarians with intracranial meningiomas in a single institution.

Methods: The Tumor Registry (2004-2021) was used to identify octogenarian patients (ages 80-89) diagnosed with intracranial meningioma. Primary endpoints were 1-year survival and functional outcome measured with mRS postsurgery. Kaplan-Meier, univariable Log-rank tests, and multivariable Cox hazards proportional regression models were used for assessing factors associated with overall survival (OS) in octogenarians with meningiomas who underwent surgery; logistic regression and McNemar's were used to further characterize risk factors affecting functional surgical outcome at 1 year.

Results: Thirty octogenarians with intracranial meningioma who underwent surgery were identified. Median age was 82.5 years and 66.6% were female patients. The 1-year median postsurgical survival probability for all octogenarians with meningioma was 86.3% and no intraoperative mortality was observed. Frailty (mFI-5, p = 0.84), tumor grade (p = 0.11), tumor size (p = 0.22), extent of resection (p = 0.35), and Karnofsky scale on admission (p = 0.93) did not significantly affect the survival in octogenarians with meningiomas which were treated surgically. The 1-year postoperative functional status of octogenarian meningioma patients who underwent surgery was significantly improved compared to pre-op mRS (McNemar's chi-squared = 9.6, df = 1, p-value = 0.001946).

Conclusion: In octogenarians with meningiomas, surgical intervention significantly improves the pre-operative modified Rankin Scale at 1 year postsurgery in this cohort.

Keywords: Functional; Meningioma; Octogenarian; Survival; mRS.

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References

    1. D’Andrea G, Roperto R, Caroli E, Crispo F, Ferrante L (2005) Thirty-seven cases of intracranial meningiomas in the ninth decade of life: our experience and review of the literature. Neurosurgery 56(5):956–960 - PubMed
    1. Dobran M, Marini A, Nasi D, Liverotti V, Benigni R, Iacoangeli M, Scerrati M (2018) Surgical treatment and outcome in patients over 80 years old with intracranial meningioma. Clin Neurol Neurosurg 167:173–176 - DOI - PubMed
    1. Eichberg DG, Di L, Shah AH, Luther E, Richardson AM, Sarkiss CA, Ivan ME, Komotar RJ (2019) Brain tumor surgery is safe in octogenarians and nonagenarians: a single-surgeon 741 patient series. World Neurosurg 132:e185–e192 - DOI - PubMed
    1. Feng S, Li J, Fan F, et al (2022) Prognostic factors and treatment strategies for elderly patients with malignant meningioma: a SEER Population-Based Study. Front Oncol 0:2070
    1. Kästner S, Oertel MF, Scharbrodt W, Krause M, Böker DK, Deinsberger W (2006) Erratum: Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH (Acta Neurochirurgica (2005) 147 (1271–1279) DOI https://doi.org/10.1007/s00701-005-0633-0 ). Acta Neurochir (Wien) 148(3):369

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