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. 2023 Oct 3;12(10):12.
doi: 10.1167/tvst.12.10.12.

Association of Subretinal Fluid Duration and Baseline Chorioretinal Structure With Optical Coherence Tomography in Central Serous Chorioretinopathy

Takafumi Suzuki  1   2 , Hirofumi Sasajima  1   3 , Chisato Otaki  1 , Yoshiki Ueta  1 , Hideo Tate  1
Affiliations

Association of Subretinal Fluid Duration and Baseline Chorioretinal Structure With Optical Coherence Tomography in Central Serous Chorioretinopathy

Takafumi Suzuki et al. Transl Vis Sci Technol. .

Abstract

Purpose: This study investigated the association between subretinal fluid (SRF) duration and baseline chorioretinal structure in patients with naïve (first-episode and untreated) central serous chorioretinopathy (CSC).

Methods: We divided 59 patients into non-prolonged (<3 months) and prolonged (>3 months) groups based on SRF fluid persistence from the initial visit. The follow-up period varied as the shorter duration was chosen between SRF disappearance time and 3 months from the initial visit. We measured the central retinal thickness (CRT), central choroidal thickness (CCT), SRF height (SRFH), and outer nuclear layer thickness (ONL) using spectral-domain optical coherence tomography (SD-OCT) at the initial visit and recorded SRF duration. We compared these parameters between the groups, conducted multivariate analysis for SRF duration of more than 3 months, and investigated the correlation among CCT and CRT, SRFH, or ONL, and among SRF duration and CRT, CCT, SRFH, or ONL.

Results: CCT was significantly thicker in the prolonged than in the non-prolonged group at the initial visit (P = 0.044) and significantly correlated with CRT and SRFH (P = 0.007, r = 0.35 and P = 0.002, r = 0.39). SRF duration significantly correlated with CRT and SRFH (P = 0.009, r = 0.40 and P = 0.003, r = 0.41). The optimal model for SRF duration more than 3 months included age (P = 0.054) and CCT (P = 0.008).

Conclusions: Thicker baseline CCT can lead to a longer SRF duration in naïve CSC.

Translational relevance: This association aids in early detection of cases at a higher risk of prolonged SRF.

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Conflict of interest statement

Disclosure: T. Suzuki, None; H. Sasajima, None; C. Otaki, None; Y. Ueta, None; H. Tate, None

Figures

Figure 1.
Figure 1.
Representative cases in the current study. OCT image at the initial visit in the non-prolonged group (A) shows that CRT was 466 µm, CCT was 382 µm, SRFH was 348 µm, and ONL was 67 µm. OCT image at the initial visit in the prolonged group (B) shows that CRT was 536 µm, CCT was 486 µm, SRFH was 409 µm, and ONL was 88 µm. The SRF improved in the non-prolonged group after 3 months (C), while it persisted in the prolonged group for 3 months (D). OCT, optical coherence tomography; CRT, central retinal thickness; CCT, central choroidal thickness; SRFH, subretinal fluid height; ONL, outer nuclear layer.
Figure 2.
Figure 2.
Correlation between CCT and CRT. CCT was significantly correlated with CRT (P = 0.007, r = 0.35).
Figure 3.
Figure 3.
Correlation between CCT and SRFH. CCT was significantly correlated with SRFH (P = 0.002, r = 0.39).
Figure 4.
Figure 4.
Correlation between SRF duration and CRT. SRF duration was significantly correlated with CRT (P = 0.009, r = 0.40). SRF, subretinal fluid.
Figure 5.
Figure 5.
Correlation between SRF duration and SRFH. SRF duration was significantly correlated with SRFH (P = 0.003, r = 0.41).
See this image and copyright information in PMC

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