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Comment
. 2023 Nov 13;41(11):1841-1843.
doi: 10.1016/j.ccell.2023.09.015. Epub 2023 Oct 12.

Co-op CARs for targeting acute myeloid leukemia

Taisuke Kondo  1 , Naomi Taylor  2
Affiliations
Comment

Co-op CARs for targeting acute myeloid leukemia

Taisuke Kondo et al. Cancer Cell. .

Abstract

Chimeric antigen receptor (CAR) T cell therapies are limited by antigen escape and on-target/off-tumor toxicity. In addressing these challenges, Haubner et al. develop an "IF-BETTER" strategy. Their combinatorial chimeric co-stimulatory receptor with an attenuated CAR enhances acute myeloid leukemia (AML) killing while protecting healthy progenitors, highlighting the potential to leverage cooperative CAR designs.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Cooperative CAR targeting to selectively eliminate AML and minimize escape.
    Haubner S, Mansilla-Soto J, Nataraj S, Kogel F, Chang Q, de Stanchina E, Lopez M, Ng MR, Fraser K, Subklewe M, Park JH, Wang X, Rivière I, Sadelain M. Haubner S, et al. Cancer Cell. 2023 Nov 13;41(11):1871-1891.e6. doi: 10.1016/j.ccell.2023.09.010. Epub 2023 Oct 5. Cancer Cell. 2023. PMID: 37802054 Free PMC article.

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