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Review
. 2023 Oct 4;24(19):14898.
doi: 10.3390/ijms241914898.

Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease

Victoria Chaoul  1 , Emanuel-Youssef Dib  2 , Joe Bedran  1 , Chakib Khoury  2 , Omar Shmoury  1 , Frédéric Harb  2 , Jihane Soueid  1
Affiliations
Review

Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease

Victoria Chaoul et al. Int J Mol Sci. .

Abstract

Neurological diseases, including neurodegenerative and neurodevelopmental disorders, affect nearly one in six of the world's population. The burden of the resulting deaths and disability is set to rise during the next few decades as a consequence of an aging population. To address this, zebrafish have become increasingly prominent as a model for studying human neurological diseases and exploring potential therapies. Zebrafish offer numerous benefits, such as genetic homology and brain similarities, complementing traditional mammalian models and serving as a valuable tool for genetic screening and drug discovery. In this comprehensive review, we highlight various drug delivery techniques and systems employed for therapeutic interventions of neurological diseases in zebrafish, and evaluate their suitability. We also discuss the challenges encountered during this process and present potential advancements in innovative techniques.

Keywords: Alzheimer’s disease; Parkinson’s disease; autism spectrum disorders; drug delivery systems; human neurological disease modeling; traumatic brain injury; zebrafish.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Techniques employed for drug administration in zebrafish and their distinctions concerning the mode of administration.
See this image and copyright information in PMC

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