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Review
. 2023 Sep 24;12(19):6162.
doi: 10.3390/jcm12196162.

A Systematic Review on Postoperative Antibiotic Prophylaxis after Pediatric and Adult Male Urethral Reconstruction

Łukasz Białek  1 , Marta Rydzińska  1 , Malte W Vetterlein  2 , Jakub Dobruch  1 , Michał A Skrzypczyk  1 ; Trauma and Reconstructive Urology Working Party of the European Association of Urology Young Academic Urologists
Affiliations
Review

A Systematic Review on Postoperative Antibiotic Prophylaxis after Pediatric and Adult Male Urethral Reconstruction

Łukasz Białek et al. J Clin Med. .

Abstract

In the era of antibiotic overuse and increasing antibiotic resistance, there is a gap in evidence regarding antibiotic stewardship, and in particular, perioperative antibiotic prophylaxis after urethral reconstruction. The aim of this systematic review was to evaluate the effectiveness and relevance of postoperative antibiotic prophylaxis after male pediatric and adult urethral reconstruction. An online search of MEDLINE database via PubMed was performed. The systematic review was registered in PROSPERO (CRD42022348555) and was conducted according to the PRISMA guidelines and AMSTAR 2 checklist. A narrative synthesis of included studies was performed. After the screening of 1176 publications, six studies regarding antibiotic prophylaxis after hypospadias reconstruction and two studies regarding antibiotic prophylaxis after urethroplasty in adults were eligible to be included in the systematic review. All but one of the studies on hypospadias repair showed no benefit from postoperative antibiotic prophylaxis. The level of evidence on postoperative antibiotic prophylaxis after urethroplasty in adults is low. Neither of the two studies included in the review showed a benefit from antibiotic use. Postoperative prophylaxis after hypospadias repair is not effective in preventing urinary tract infections and wound infections. It seems that the use of postoperative prophylaxis after urethroplasty in adults is also not beneficial, but there is a high need for high-quality scientific data.

Keywords: antibiotic prophylaxis; hypospadias; urethral reconstruction; urethral stricture; urinary tract infection; wound infection.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
See this image and copyright information in PMC

References

    1. Lumen N., Campos-Juanatey F., Greenwell T., Martins F.E., Osman N.I., Riechardt S., Waterloos M., Barratt R., Chan G., Esperto F., et al. European Association of Urology Guidelines on Urethral Stricture Disease (Part 1): Management of Male Urethral Stricture Disease. Eur. Urol. 2021;80:190–200. doi: 10.1016/j.eururo.2021.05.022. - DOI - PubMed
    1. Wessells H., Angermeier K.W., Elliott S., Gonzalez C.M., Kodama R., Peterson A.C., Reston J., Rourke K., Stoffel J.T., Vanni A.J., et al. Male Urethral Stricture: American Urological Association Guideline. J. Urol. 2017;197:182–190. doi: 10.1016/j.juro.2016.07.087. - DOI - PubMed
    1. Santucci R., Eisenberg L. Urethrotomy has a much lower success rate than previously reported. J. Urol. 2010;183:1859–1862. doi: 10.1016/j.juro.2010.01.020. - DOI - PubMed
    1. Castagnetti M., El-Ghoneimi A. Surgical management of primary severe hypospadias in children: Systematic 20-year review. J. Urol. 2010;184:1469–1474. doi: 10.1016/j.juro.2010.06.044. - DOI - PubMed
    1. Hulscher M.E.J.L., Grol R.P.T.M., van der Meer J.W.M. Antibiotic prescribing in hospitals: A social and behavioural scientific approach. Lancet Infect. Dis. 2010;10:167–175. doi: 10.1016/S1473-3099(10)70027-X. - DOI - PubMed

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