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. 2023 Sep 23;13(19):3032.
doi: 10.3390/diagnostics13193032.

NT-proBNP-Possible Prognostic Marker in Pregnant Patients with Associated Cardiovascular Risk Factors and SARS-CoV-2 Infection

Carmen-Ioana Marta  1   2 , Anca Laura Maghiari  3 , Elena Bernad  2   4   5 , Lavinia Stelea  2   4 , Brenda Bernad  6 , Lioara Boscu  6 , Radu Neamtu  2   4 , Adrian Gluhovschi  2   4 , Mircea Diaconu  2   4 , Catalin Dumitru  2   4 , Bogdan Sorop  2   4 , Katalin Babes  1   7
Affiliations

NT-proBNP-Possible Prognostic Marker in Pregnant Patients with Associated Cardiovascular Risk Factors and SARS-CoV-2 Infection

Carmen-Ioana Marta et al. Diagnostics (Basel). .

Abstract

Background: N-terminal pro brain-type natriuretic peptide (NT-proBNP) is a practical biomarker in the clinical pathologies where the ventricle is under stress and particularly stretched in the general population. The study aims to compare the value of NT-proBNP and its importance in the prognosis and severity of the cases involving pregnant patients with SARS-CoV-2 infection and cardiovascular risk factors to those of low-risk pregnant patients, mainly by analysing their symptoms, administered medication, days of hospitalization and severity of the viral disease.

Methods: The study included a total of eighty-three pregnant patients who underwent natural birth or caesarean section at out hospital. NT-proBNP levels were analyzed at hospital admission as a potential cardiovascular marker. A comparative analysis was performed between pregnant patients with cardiovascular risk factors and pregnant patients without cardiovascular risk factors regarding NT-proBNP values.

Results: Pregnant patients with SARS-CoV-2 infection and cardiovascular risk factors had higher values of NT-proBNP in comparison to pregnant patients without cardiovascular risk factors.

Conclusions: NT-proBNP testing in pregnant patients with SARS-CoV-2 infection can be a relatively important marker to be taken into consideration when it comes to the management, treatment and outcome of the cases, especially when it comes to women with associated cardiovascular risk factors.

Keywords: NT-proBNP; SARS-CoV-2; cardiovascular diseases; peripartum cardiomiopathy; pregnancy complications.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Standard deviation between groups.
See this image and copyright information in PMC

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