Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Oct 2;13(19):3111.
doi: 10.3390/diagnostics13193111.

Unexplained and Unexpected Pediatric Deaths: Forensic Review and New Perspectives

Affiliations
Review

Unexplained and Unexpected Pediatric Deaths: Forensic Review and New Perspectives

Isabella Aquila et al. Diagnostics (Basel). .

Abstract

Unexplained and unexpected pediatric deaths are a major challenge in global healthcare. The role of the forensic pathologist is crucial in determining the cause and manner of death in these cases, although to date, there are many limitations in post-mortem diagnosis. The role of the autopsy and related forensic investigations become a fundamental tool to investigate and give an explanation for an unacceptable event, considering the young age of the victims. From this point of view, even today, it is necessary that this phenomenon is correctly recorded through standardized systems and universally accepted methods. Furthermore, it is essential that scientific research on this topic is increased through the implementation of universally accepted operating protocols recognizing real risk factors in order to prevent such events. The purpose of the study is to offer a review of the state of the art about unexplained pediatric death and, above all, to propose an international reporting platform, extending proper investigations not only to judicial cases but also to all the other cases of unexpected pediatric death.

Keywords: autopsy in pediatric death; standardization; unexpected pediatric death; unexplained pediatric death.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Shapiro-Mendoza C.K., Woodworth K.R., Cottengim C.R., Lambert A.B.E., Harvey E.M., Monsour M., Parks S.E., Barfield W.D. Sudden Unexpected Infant Deaths: 2015–2020. Pediatrics. 2023;151:e2022058820. doi: 10.1542/peds.2022-058820. - DOI - PMC - PubMed
    1. Boyer B.T., Lowell G.S., Roehler D.R., Quinlan K.P. Racial and ethnic disparities of sudden unexpected infant death in large US cities: A descriptive epidemiological study. Inj. Epidemiol. 2022;9:12. doi: 10.1186/s40621-022-00377-7. - DOI - PMC - PubMed
    1. Krous H.F., Beckwith J.B., Byard R.W., Rognum T.O., Bajanowski T., Corey T., Cutz E., Hanzlick R., Keens T.G., Mitchell E.A. Sudden Infant Death Syndrome and Unclassified Sudden Infant Deaths: A Definitional and Diagnostic Approach. Pediatrics. 2004;114:234–238. doi: 10.1542/peds.114.1.234. - DOI - PubMed
    1. Burns K.M., Cottengim C., Dykstra H., Faulkner M., Lambert A.B.E., MacLeod H., Novak A., Parks S.E., Russell M.W., Shapiro-Mendoza C.K., et al. Epidemiology of Sudden Death in a Population-Based Study of Infants and Children. J. Pediatr. X. 2020;2:100023. doi: 10.1016/j.ympdx.2020.100023. - DOI - PMC - PubMed
    1. Leitner D.F., William C., Faustin A., Askenazi M., Kanshin E., Snuderl M., McGuone D., Wisniewski T., Ueberheide B., Gould L., et al. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathol. 2022;143:585–599. doi: 10.1007/s00401-022-02414-7. - DOI - PMC - PubMed

LinkOut - more resources