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Randomized Controlled Trial
. 2023 Sep 30;15(19):4233.
doi: 10.3390/nu15194233.

Efficacy of Time-Restricted Eating and Behavioral Economic Intervention in Reducing Fasting Plasma Glucose, HbA1c, and Cardiometabolic Risk Factors in Patients with Impaired Fasting Glucose: A Randomized Controlled Trial

Unyaporn Suthutvoravut  1 , Thunyarat Anothaisintawee  1   2 , Suparee Boonmanunt  2 , Sarunporn Pramyothin  3 , Sukanya Siriyothin  2 , John Attia  4 , Gareth J McKay  5 , Sirimon Reutrakul  6 , Ammarin Thakkinstian  2
Affiliations
Randomized Controlled Trial

Efficacy of Time-Restricted Eating and Behavioral Economic Intervention in Reducing Fasting Plasma Glucose, HbA1c, and Cardiometabolic Risk Factors in Patients with Impaired Fasting Glucose: A Randomized Controlled Trial

Unyaporn Suthutvoravut et al. Nutrients. .

Abstract

This randomized controlled trial is aimed at assessing the efficacy of combining time-restricted eating (TRE) with behavioral economic (BE) interventions and comparing it to TRE alone and to the usual care for reducing fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), and other cardiometabolic risk factors among patients with impaired fasting glucose (IFG). Seventy-two IFG patients aged 18-65 years were randomly allocated for TRE with BE interventions (26 patients), TRE alone (24 patients), or usual care (22 patients). Mean FPG, HbA1c, and other cardiometabolic risk factors among the three groups were compared using a mixed-effect linear regression analysis. Mean body weight, FPG, HbA1c, fasting insulin, and lipid profiles did not significantly differ among the three groups. When considering only patients who were able to comply with the TRE protocol, the TRE group showed significantly lower mean FPG, HbA1c, and fasting insulin levels compared to the usual care group. Our results did not show significant differences in body weight, blood sugar, fasting insulin, or lipid profiles between TRE plus BE interventions, TRE alone, and usual care groups. However, TRE might be an effective intervention in lowering blood sugar levels for IFG patients who were able to adhere to the TRE protocol.

Keywords: behavioral economic intervention; cardiometabolic risk; impaired fasting glucose; randomized controlled trial; time-restricted eating.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Participant flow diagram.
Figure 2
Figure 2
Mean changes in fasting plasma glucose, HbA1c, and body weight in time-restricted eating plus behavioral economic intervention, time-restricted alone, and usual care groups: (A) Fasting plasma glucose; (B) HbA1c; (C) Body weight.
See this image and copyright information in PMC

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