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Multicenter Study
. 2024 Feb;40(2):435-444.
doi: 10.1007/s00381-023-06179-6. Epub 2023 Oct 14.

Trends in pediatric CNS tumors in Armenia: a multicenter retrospective study

Julieta Hoveyan  1   2 , Eduard Asatryan  3 , Henrik Grigoryan  4   5 , Shushan Hovsepyan  6   7   5 , Anna Avagyan  4 , Lusine Hakobyan  6   5 , Lilit Sargsyan  6   5 , Samvel Iskanyan  6 , Manushak Avagyan  5 , Saten Hovhannisyan  6 , Irina Melnichenko  6 , Mariam Minasyan  6   5 , Ruzanna Papyan  6   7   5 , Narek Manukyan  8 , Armine Lazaryan  9 , Samvel Danelyan  10 , Armen Muradyan  11 , Jemma Arakelyan  12 , Ibrahim Qaddoumi  13   14 , Frederick Boop  14 , Armen Mkhitharyan  15   16 , Martin Harutyunyan  17 , Gevorg Tamamyan  6   7   4   5 , Samvel Bardakhchyan  7   17
Affiliations
Multicenter Study

Trends in pediatric CNS tumors in Armenia: a multicenter retrospective study

Julieta Hoveyan et al. Childs Nerv Syst. 2024 Feb.

Abstract

Purpose: Central nervous system (CNS) tumors are the most common solid malignancies in children worldwide, including in Armenia. The current study aims to analyze epidemiological data, treatment, and outcomes of children and young adults (≤25 years) with CNS tumors in Armenia during the last 26 years.

Methods: We collected data from pediatric and young adult patients treated in selected sites in Armenia from 1st January 1995 to 31st December 2020. Incidence by sex, age at diagnosis, time from first complaints to diagnosis, histopathology results, treatment strategies, complications, and overall survival (OS) rates were calculated.

Results: The multicenter data analysis revealed 149 patients with diagnosed primary CNS tumors over 26 years. Among them, 84 (56.4%) were male. The median age at diagnosis was 7 years (range, 3 months to 25 years), and the median time from the first complaints to diagnosis was 2 months (range, 1 week to 70 months). Medulloblastomas and other embryonal tumors (47), low-grade gliomas (32), and high-grade gliomas (22) were the most commonly diagnosed malignancies. Ependymomas, craniopharyngiomas, germ cell tumors, and other malignancies were observed in 22 patients. For 26 patients, no histopathological or radiological diagnosis was available. Follow-up information was available for 98 (65.8%) patients. The 5-year OS rate for the whole study group was 67.7%.

Conclusion: Consistent with international data, embryonal tumors, and gliomas were the most commonly diagnosed CNS malignancies in Armenia. Multimodal treatment was often not available in Armenia during the study period, especially for early cases.

Keywords: Armenia; CNS tumors; Developing country; Epidemiology.

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References

    1. Linabery AM, Ross JA (2008) Trends in childhood cancer incidence in the U.S. (1992-2004). Cancer 112(2):416–432. https://doi.org/10.1002/cncr.23169 - DOI - PubMed
    1. Withrow DR, Berrington de Gonzalez A, Lam CJK, Warren KE, Shiels MS (2019) Trends in Pediatric Central Nervous System Tumor Incidence in the United States, 1998–2013. Cancer Epidemiol Biomarkers Prev 28(3):522–530. https://doi.org/10.1158/1055-9965.EPI-18-0784 . Epub 2018 Nov 21. PMID: 30464022; PMCID: PMC6401271 - DOI - PubMed
    1. Liu YL, Lo WC, Chiang CJ, Yang YW, Lu MY, Hsu WM, Ho WL, Li MJ, Miser JS, Lin DT, Lai MS (2015) Incidence of cancer in children aged 0–14 years in Taiwan, 1996–2010. Cancer Epidemiol 39(1):21–8. https://doi.org/10.1016/j.canep.2014.11.010 . Epub 2015 Jan 16 PMID: 25599927 - DOI - PubMed
    1. Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS (2021) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol 23(12 Suppl 2):iii1–iii105. https://doi.org/10.1093/neuonc/noab200 . PMID: 34608945; PMCID: PMC8491279 - DOI - PubMed - PMC
    1. Kaatsch P (2010) Epidemiology of childhood cancer. Cancer Treat Rev 36(4):277–85. https://doi.org/10.1016/j.ctrv.2010.02.003 . Epub 2010 Mar 15 PMID: 20231056 - DOI - PubMed

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