NM and ARR visited the individuals and contributed to writing the article. SN designed the study and contributed to writing the report. MB executed the laboratory assays. DM and MRG coordinated the virological activities and contributed to the reviewing of the manuscript. SD did the statistical analyses and contributed to the writing of the manuscript. RL collected the clinical data. CC visited the individuals and contributed to the review of the manuscript. AC and CUF coordinated clinical activities and contributed to the review of the manuscript. All authors have read and agreed to the published version of the manuscript. All authors had direct access and verified the underlying data reported in the manuscript; had full access to all the data in the study and accept responsibility to submit for publication; and have seen and approved of the final text. We declare no competing interests. ARR and SN directly accessed and verified the underlying data reported in the manuscript and all authors potentially had access to all data. SN and DM were responsible for the decision to submit the manuscript. NM and ARR contributed equally. SN and DM contributed equally. Individuals included in the study signed written informed consent to include case details and personal information in the published version of the manuscript in all formats. AC has received personal fees for advisory boards, speaker panels, and educational materials from Gilead Sciences, ViiV Healthcare, Janssen-Cilag, Merck Sharp & Dohme, and Theratechnlogies. SN has received personal fees for advisory boards, speaker panels, and educational materials from Gilead Sciences, ViiV Healthcare, Janssen-Cilag, Merck Sharp & Dohme. ARR, SD, RL, CC, DM, MRG, MB, and NM declare no competing interests. All data collected in the study are available on reasonable request, after approval of a proposal, to the corresponding author (raccagni.angelo@hsr.it), including deidentified single participant data. The data can be requested from publication onwards. The data are not publicly available for ethical reasons.