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. 1987 Jan;61(1):206-8.
doi: 10.1128/JVI.61.1.206-208.1987.

Receptor-binding characteristics of monoclonal antibody-selected antigenic variants of influenza virus

P A Underwood, J J Skehel, D C Wiley

Receptor-binding characteristics of monoclonal antibody-selected antigenic variants of influenza virus

P A Underwood et al. J Virol. 1987 Jan.

Abstract

Erythrocytes modified to different extents with periodate were used in hemagglutination assays to investigate the binding properties of antihemagglutinin monoclonal antibody-selected antigenic variants of X-31 influenza virus. The results allowed differentiation of groups of variants and are discussed in relation to the nature of the amino acid substitutions in the variant hemagglutinins and their molecular locations relative to the receptor-binding site.

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