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Review
. 2024 Mar;40(3):e3740.
doi: 10.1002/dmrr.3740. Epub 2023 Oct 15.

Non-coding RNAs in diabetic foot ulcer- a focus on infected wounds

Boquan Qin  1 , Qi Peng  1 , Hongxian Dong  1 , Lei Lei  2 , Shizhou Wu  1
Affiliations
Review

Non-coding RNAs in diabetic foot ulcer- a focus on infected wounds

Boquan Qin et al. Diabetes Metab Res Rev. 2024 Mar.

Abstract

Diabetes mellitus is associated with a wide range of neuropathies, vasculopathies, and immunopathies, resulting in many complications. More than 30% of diabetic patients risk developing diabetic foot ulcers (DFUs). Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play essential roles in various biological functions in the hyperglycaemic environment that determines the development of DFU. Ulceration results in tissue breakdown and skin barrier scavenging, thereby facilitating bacterial infection and biofilm formation. Many bacteria contribute to diabetic foot infection (DFI), including Staphylococcus aureus (S. aureus) et al. A heterogeneous group of "ncRNAs," termed small RNAs (sRNAs), powerfully regulates biofilm formation and DFI healing. Multidisciplinary foot care interventions have been identified for nonhealing ulcers. With an appreciation of the link between disease processes and ncRNAs, a novel therapeutic model of bioactive materials loaded with ncRNAs has been developed to prevent and manage diabetic foot complications.

Keywords: diabetic foot ulcer; non-coding RNA; sRNA; wound healing.

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References

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