doi: 10.1016/j.ophtha.2023.10.015.
Epub 2023 Oct 13.
Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries
Swathi Kaliki
1
, Vijitha S Vempuluru
2
, Ashik Mohamed
2
, Mazin Faisal Al-Jadiry
3
, Richard Bowman
4
, Bhavna Chawla
5
, Syed Ahmer Hamid
6
, Xunda Ji
7
, Noa Kapelushnik
8
, Rejin Kebudi
9
, Purnima Rajkarnikar Sthapit
10
, Duangnate Rojanaporn
11
, Rita S Sitorus
12
, Yacoub Abdallah Yousef
13
, Ido Didi Fabian
14
; Global Retinoblastoma Study Group
Collaborators,
Affiliations
Collaborators
-
Global Retinoblastoma Study Group:
Swathi Kaliki 15 , Vijitha S Vempuluru 15 , Ashik Mohamed 15 , Rula Ahmed Abdulqader 16 , Priyanka Aggarwal 17 , Alia Ahmad 18 , Marliyanti Nur Rahmah Akib 19 , Saleh A Al Mesfer 20 , Mouroge Hashim Al Ani 21 , Safaa A Faraj Al-Badri 3 , Ana Patricia Angeles Alcasabas 22 , Saad A Al-Dahmash 23 , Christiane Al-Haddad 24 , Hamoud Hodeish Yahya Al-Hussaini 25 , Mazin Faisal Al-Jadiry 3 , Usama Al-Jumaily 26 , Hind Manaa Alkatan 23 , Ali Abdul Razzaq Mahmood Al-Mafrachi 27 , Athar Abdul Samad Majeed Al-Shaheen 16 , Entissar Hadi Al-Shammary 28 , Primawita Oktarima Amiruddin 29 , Inggar Armytasari 30 , Nicholas John Astbury 31 , Hatice Tuba Atalay 32 , Eda Ataseven 33 , La-Ongsri Atchaneeyasakul 34 , Ruhengiz Balayeva 35 , Covadonga Bascaran 31 , Ainura Suranovna Begimkulova 36 , Anirban Bhaduri 37 , Sunil Bhat 38 , Arpita Bhattacharyya 39 , Sharon Blum 40 , Richard Bowman 41 , Jassada Buaboonnam 34 , Matthew J Burton 31 , Shani Caspi 42 , Shabana Chaudhry 43 , Bhavna Chawla 5 , Wensi Chen 44 , Tsengelmaa Chuluunbat 45 , Wantanee Dangboon 46 , Anirban Das 39 , Pranab Das 47 , Sima Das 48 , Yi Du 49 , Gagan Dudeja 38 , I Wayan Eka Sutyawan 50 , Zehra Fadoo 51 , Mohammad Faranoush 52 , Allen Foster 31 , Shahar Frenkel 53 , Fariba Ghassemi 54 , Nir Gomel 40 , D Sanjeeva Gunasekera 55 , Ahmet K Gündüz 56 , Himika Gupta 57 , Sanjiv Gupta 58 , Vineeta Gupta 17 , Syed Ahmer Hamid 59 , Norhafizah Hamzah 60 , Murat Hasanreisoglu 32 , Shadab Hassan 61 , Huda Awni Haydar 21 , Suradej Hongeng 62 , Allawi Noor Hussein Al-Janabi 63 , Ziyavuddin Islamov 64 , Teyyeb Azeem Janjua 65 , Irfan Jeeva 51 , Xunda Ji 7 , Dong Hyun Jo 66 , Mehmet Kantar 33 , Noa Kapelushnik 8 , Rejin Kebudi 67 , Jonny Keomisy 68 , Zohora Jameela Khan 69 , Hussain Ahmed Khaqan 70 , Vikas Khetan 71 , Alireza Khodabande 54 , Jeong Hun Kim 72 , Hayyam Kiratli 73 , Irem Koç 73 , Kittisak Kulvichit 74 , Mayasari Wahyu Kuntorini 29 , Cairui Li 75 , Kaijun Li 49 , Ben Limbu 76 , ChunHsiu Liu 77 , Delfitri Lutfi 78 , Amita Mahajan 79 , Puja Maitra 71 , Emil Kojoshovich Makimbetov 36 , Azza M Y Maktabi 20 , Lyazat Manzhuova 80 , Sidra Masud 51 , Azim Mehrvar 81 , Vikas Menon 82 , Gary John V Mercado 22 , Divyansh Kailash Chandra Mishra 83 , Mona Tayseer Mohammad 84 , Sangeeta Sanjay Mudaliar 57 , Asma Mushtaq 18 , Akshay Gopinathan Nair 85 , Sundaram Natarajan 86 , Yetty Movieta Nency 87 , Vladimir Neroev 88 , Murtuza Nuruddin 89 , Halimah Pagarra 19 , Mahesh Shanmugam Palanivelu 83 , Ruzanna Papyan 90 , Jacob Pe'er 53 , Vladimir Polyakov 91 , Ali Omer Qadir 92 , Seema Qayyum 18 , Jiang Qian 93 , BoonLong Quah 81 , Ardizal Rahman 94 , Purnima Rajkarnikar 65 , Rajesh Ramanjulu 70 , Riffat Rashid 83 , Duangnate Rojanaporn 11 , Soma Rani Roy 89 , Raya Hamad Saab 95 , Svetlana Saakyan 88 , Ahmed Hatem Sabhan 3 , Rohit Saiju 76 , Phayvanh Sayalith 68 , Ahad Sedaghat 96 , Rachna Seth 97 , Shawkat Ara Shakoor 98 , Manoj Kumar Sharma 99 , Sorath Noorani Siddiqui 61 , Usha Singh 100 , Penny Singha 46 , Rita S Sitorus 101 , Hendrian D Soebagjo 78 , Sadia Sultana 102 , Xiantao Sun 103 , Eddy Supriyadi 30 , Supawan Surukrattanaskul 104 , Shigenobu Suzuki 105 , Deborah Tan 106 , Jing Tang 7 , Maryam Tashvighi 81 , Kok Hoi Teh 60 , Edi Setiawan Tehuteru 107 , Abdullah Dahan M Thawaba 25 , Helen Toledano 108 , Doan Le Trang 109 , Devjyoti Tripathy 110 , Samuray Tuncer 111 , Emel Unal 112 , Tatiana L Ushakova 91 , Rustam Usmanov 64 , Nishant Verma 58 , Andi Arus Victor 101 , Victoria Vishnevskia-Dai 8 , Yi-Zhuo Wang 113 , Nutsuchar Wangtiraumnuay 104 , Widiarti Pandu Riono 107 , Atchareeya Wiwatwongwana 114 , Damrong Wiwatwongwana 114 , Emily S Wong 115 , Phanthipha Wongwai 116 , Si-Qi Wu 117 , Daoman Xiang 44 , Yishuang Xiao 117 , Bing Xu 75 , Kang Xue 93 , Jason C Yam 115 , Huasheng Yang 118 , Muhammad Amer Yaqub 65 , Vera A Yarovaya 119 , Andrey A Yarovoy 119 , Huijing Ye 118 , Yacoub Abdallah Yousef 84 , Putu Yuliawati 31 , Yi Zhang 113 , Nida Zia 59 , Marcia Zondervan 31 , Ido Didi Fabian 120
Affiliations
- 1 The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Hyderabad, India. Electronic address: kalikiswathi@yahoo.com.
- 2 The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Hyderabad, India.
- 3 Pediatric Oncology Unit, Children Welfare Teaching Hospital, Medical City, College of Medicine, University of Baghdad, Bagdad, Iraq.
- 4 International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Department of Ophthalmology, Great Ormond Street Children's Hospital, London, United Kingdom.
- 5 Ocular Oncology Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
- 6 Department of Ophthalmology, The Indus Hospital, Karachi, Pakistan.
- 7 Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- 8 Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.
- 9 Department of Pediatric Hematology-Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey.
- 10 Department of Ophthalmology, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
- 11 Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
- 12 Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
- 13 Department of Ophthalmology, King Hussein Cancer Center, Amman, Jordan.
- 14 International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.
- 15 The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, India.
- 16 Basra Children Specialty Hospital, Basra, Iraq.
- 17 Department of Pediatrics, Banaras Hindu University, Varanasi, India.
- 18 The Children' Hospital & the Institute of Child Health, Lahore, Pakistan.
- 19 RS Dr. Wahidin Sudirohusodo, Makassar, Indonesia.
- 20 King Khalid eye specialist hospital, Riyadh, Saudi Arabia.
- 21 Hawler Medical University, Erbil, Iraq.
- 22 University of the Philippines - Philippine General Hospital, Manila, Philippines.
- 23 College of Medicine, King Saud University, Riyadh, Saudi Arabia.
- 24 Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon.
- 25 Pediatric Oncology Department, National Oncology Center, Sana'a, Yemen.
- 26 Imam Hussein Cancer Center, Kerbala, Iraq.
- 27 Ibn AlHaitham Teaching Eye Hospital, Baghdad, Iraq.
- 28 Oncology Unit, Child's Central Teaching Hospital, Baghdad, Iraq.
- 29 National Eye Center-Cicendo Eye Hospital, Bandung, Indonesia.
- 30 Sardjito Hospital-Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
- 31 International Centre for Eye Health London School of Hygiene & Tropical Medicine, London, UK.
- 32 Gazi University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
- 33 Ege University, School of Medicine, Division of Pediatric Oncology, Izmir, Turkey.
- 34 Siriraj Hospital Mahidol University, Bangkok, Thailand.
- 35 Zarifa Aliyeva National Centre of Ophthalmology, Baku, Azerbaijan.
- 36 National Center of Oncology and Hematology, Bishkek, Kyrgyzstan.
- 37 Susrut Eye Foundation & Research Institute, Kolkata, India.
- 38 Department of Pediatric Hematology and Oncology, Narayana Health City, Bangalore, India.
- 39 Department of Pediatric Hematology Oncology, Tata Medical Center, Kolkata, India.
- 40 Tel Aviv Sourasky Medical Center and The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
- 41 International Centre for Eye Health London School of Hygiene & Tropical Medicine, London, UK; Ophthalmology Department, Great Ormond Street Children's Hospital, London, UK.
- 42 Pediatric Oncology, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.
- 43 Paediatric Ophthalmology Department, Mayo Hospital & College of Allied Visual Sciences (COAVS), King Edward Medical University, Lahore, Pakistan.
- 44 Department of Pediatric Ophthalmology, Guangzhou Children's Hospital and Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
- 45 National Center for Maternal and Children Health of Mongolia, Ulaanbaatar, Mongolia.
- 46 Department of Ophthalmology, Songklanagarind Hospital, Prince of a Songkla university, Songkla, Thailand.
- 47 The Calcutta Medical Research Institute, Kolkata, India.
- 48 Ocular Oncology Services, Dr Shroff's Charity Eye Hospital, New Delhi, India.
- 49 Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
- 50 Departement of Opthalmology Udayana University, Sanglah Eye Hospital, Bali, Indonesia.
- 51 Aga Khan University, Karachi, Pakistan.
- 52 Pediatric Growth and Development Research Center, Institute of Endocrinology, Iran University of Medical Sciences, Rasool Akram Hospital, Tehran, Iran.
- 53 Hadassah Hebrew University Medical Center, Jerusalem, Israel.
- 54 Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
- 55 National Cancer Institute, Maharagama, Sri Lanka.
- 56 Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
- 57 Bai Jerbai Wadia Hospital for Children, Mumbai, India.
- 58 King George's Medical University, Lucknow, Uttar Pradesh, India.
- 59 The Indus Hospital, Karachi, Pakistan.
- 60 Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
- 61 Department of Pediatric Ophthalmology and Strabismus, Al Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
- 62 Department of pediatrics Faculty of medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
- 63 Oncology Unit, Child Central Teaching Hospital, Baghdad, Iraq.
- 64 National Cancer Center of Uzbekistan, Tashkent, Uzbekistan.
- 65 Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
- 66 Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 67 Istanbul University, Oncology Institute, Pediatric Hematology-Oncology, Istanbul, Turkey.
- 68 Mahosot Hospital, Vientiane, Laos.
- 69 Dhaka Medical College Hospital, Dhaka, Bangladesh.
- 70 Department of Ophthalmology, Post Graduate Medical Institute, Ameer Ud Din Medical College, Lahore General Hospital, Lahore, Pakistan.
- 71 Sankara Nethralaya, Chennai, India.
- 72 Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea.
- 73 Ocular Oncology Service, Hacettepe University School of Medicine, Ankara, Turkey.
- 74 Vitreo-Retina Research Unit, Department of Ophthalmology, Chulalongkorn University, Bangkok, Thailand.
- 75 The first hospital of Dali University, Yunnan Province, China.
- 76 Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
- 77 Chang Gung Memorial Hospital, Taipei, Taiwan.
- 78 Ophthalmology Department, Airlangga University - Dr. Soetomo General Hospital, Surabaya, Indonesia.
- 79 Pediatric Hematology-Oncology Unit, Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, New Delhi, India.
- 80 Scientific Centre for Pediatrics and Pediatric Surgery, Almaty, Kazakhstan.
- 81 Mahak childrens Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Tehran, Iran.
- 82 Centre for Sight, New Delhi, India.
- 83 Sankara Eye Hospital, Bangalore, India.
- 84 King Hussein Cancer Center, Amman, Jordan.
- 85 Aditya Jyot Eye Hospital, Mumbai, India; Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, India.
- 86 Aditya Jyot Eye Hospital, Mumbai, India.
- 87 Child Health Department, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
- 88 Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia.
- 89 Chittagong Eye Infirmary & Training Complex, Chittagong, Bangladesh.
- 90 Yerevan State Medical University, Department of Oncology and Pediatric Cancer and Blood Disorders Center of Armenia, Hematology Center after R.H. Yeolyan, Yerevan, Armenia.
- 91 Head and Neck Tumors Department, SRI of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Center of Oncology of Russian Federation, and Medical Academy of Postgraduate Education, Moscow, Russia.
- 92 Hiwa Cancer Hospital, Al Sulaimaniyah, Iraq.
- 93 Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
- 94 Ophthalmology Department, Dr. M. Djamil General Hospital, Medical Faculty Andalas University West Sumatra, Indonesia.
- 95 Children's Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon.
- 96 Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
- 97 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
- 98 National Institute of Ophthalmology, Dhaka, Bangladesh.
- 99 East Timor Eye Program, Dili, Timor-Leste.
- 100 Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
- 101 Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
- 102 Department of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.
- 103 Henan Children's Hospital, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, China.
- 104 Queen Sirikit National Institute of Child Health, Bangkok, Thailand.
- 105 Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Japan.
- 106 Singapore National Eye Centre and KK Women's and Children's Hospital in Singapore, Singapore.
- 107 National Cancer Center - "Dharmais" Cancer Hospital, Jakarta, Indonesia.
- 108 Department of Pediatric HematologyOncology, Schneider Children's Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.
- 109 Vietnam National Institute of Ophthalmology, Ha Noi, Vietnam.
- 110 LV Prasad Eye Institute, MTC Campus, Bhubaneswar, Odisha, India.
- 111 Istanbul University, Faculty of Medicine, Department of Ophthalmology, Ocular Oncology Service, Istanbul, Turkey.
- 112 Ankara University Department of Pediatrics, Division of Pediatric Hematology-Oncology, Ankara, Turkey.
- 113 Department of Paediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
- 114 Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand.
- 115 Hong Kong Eye Hospital, Chinese University of Hong Kong, Hong Kong, Hong Kong S.A.R.
- 116 Department of ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
- 117 Kunming Children's Hospital, Kunming, China.
- 118 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
- 119 S.Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russia.
- 120 International Centre for Eye Health London School of Hygiene & Tropical Medicine, London, UK; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.
- PMID: 37839559
- DOI: 10.1016/j.ophtha.2023.10.015
Item in Clipboard
Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries
Swathi Kaliki et al.
Ophthalmology.
2024 Apr.
Free article
Display options
Format
doi: 10.1016/j.ophtha.2023.10.015.
Epub 2023 Oct 13.
Authors
Swathi Kaliki
1
, Vijitha S Vempuluru
2
, Ashik Mohamed
2
, Mazin Faisal Al-Jadiry
3
, Richard Bowman
4
, Bhavna Chawla
5
, Syed Ahmer Hamid
6
, Xunda Ji
7
, Noa Kapelushnik
8
, Rejin Kebudi
9
, Purnima Rajkarnikar Sthapit
10
, Duangnate Rojanaporn
11
, Rita S Sitorus
12
, Yacoub Abdallah Yousef
13
, Ido Didi Fabian
14
; Global Retinoblastoma Study Group
Collaborators
-
Global Retinoblastoma Study Group:
Swathi Kaliki 15 , Vijitha S Vempuluru 15 , Ashik Mohamed 15 , Rula Ahmed Abdulqader 16 , Priyanka Aggarwal 17 , Alia Ahmad 18 , Marliyanti Nur Rahmah Akib 19 , Saleh A Al Mesfer 20 , Mouroge Hashim Al Ani 21 , Safaa A Faraj Al-Badri 3 , Ana Patricia Angeles Alcasabas 22 , Saad A Al-Dahmash 23 , Christiane Al-Haddad 24 , Hamoud Hodeish Yahya Al-Hussaini 25 , Mazin Faisal Al-Jadiry 3 , Usama Al-Jumaily 26 , Hind Manaa Alkatan 23 , Ali Abdul Razzaq Mahmood Al-Mafrachi 27 , Athar Abdul Samad Majeed Al-Shaheen 16 , Entissar Hadi Al-Shammary 28 , Primawita Oktarima Amiruddin 29 , Inggar Armytasari 30 , Nicholas John Astbury 31 , Hatice Tuba Atalay 32 , Eda Ataseven 33 , La-Ongsri Atchaneeyasakul 34 , Ruhengiz Balayeva 35 , Covadonga Bascaran 31 , Ainura Suranovna Begimkulova 36 , Anirban Bhaduri 37 , Sunil Bhat 38 , Arpita Bhattacharyya 39 , Sharon Blum 40 , Richard Bowman 41 , Jassada Buaboonnam 34 , Matthew J Burton 31 , Shani Caspi 42 , Shabana Chaudhry 43 , Bhavna Chawla 5 , Wensi Chen 44 , Tsengelmaa Chuluunbat 45 , Wantanee Dangboon 46 , Anirban Das 39 , Pranab Das 47 , Sima Das 48 , Yi Du 49 , Gagan Dudeja 38 , I Wayan Eka Sutyawan 50 , Zehra Fadoo 51 , Mohammad Faranoush 52 , Allen Foster 31 , Shahar Frenkel 53 , Fariba Ghassemi 54 , Nir Gomel 40 , D Sanjeeva Gunasekera 55 , Ahmet K Gündüz 56 , Himika Gupta 57 , Sanjiv Gupta 58 , Vineeta Gupta 17 , Syed Ahmer Hamid 59 , Norhafizah Hamzah 60 , Murat Hasanreisoglu 32 , Shadab Hassan 61 , Huda Awni Haydar 21 , Suradej Hongeng 62 , Allawi Noor Hussein Al-Janabi 63 , Ziyavuddin Islamov 64 , Teyyeb Azeem Janjua 65 , Irfan Jeeva 51 , Xunda Ji 7 , Dong Hyun Jo 66 , Mehmet Kantar 33 , Noa Kapelushnik 8 , Rejin Kebudi 67 , Jonny Keomisy 68 , Zohora Jameela Khan 69 , Hussain Ahmed Khaqan 70 , Vikas Khetan 71 , Alireza Khodabande 54 , Jeong Hun Kim 72 , Hayyam Kiratli 73 , Irem Koç 73 , Kittisak Kulvichit 74 , Mayasari Wahyu Kuntorini 29 , Cairui Li 75 , Kaijun Li 49 , Ben Limbu 76 , ChunHsiu Liu 77 , Delfitri Lutfi 78 , Amita Mahajan 79 , Puja Maitra 71 , Emil Kojoshovich Makimbetov 36 , Azza M Y Maktabi 20 , Lyazat Manzhuova 80 , Sidra Masud 51 , Azim Mehrvar 81 , Vikas Menon 82 , Gary John V Mercado 22 , Divyansh Kailash Chandra Mishra 83 , Mona Tayseer Mohammad 84 , Sangeeta Sanjay Mudaliar 57 , Asma Mushtaq 18 , Akshay Gopinathan Nair 85 , Sundaram Natarajan 86 , Yetty Movieta Nency 87 , Vladimir Neroev 88 , Murtuza Nuruddin 89 , Halimah Pagarra 19 , Mahesh Shanmugam Palanivelu 83 , Ruzanna Papyan 90 , Jacob Pe'er 53 , Vladimir Polyakov 91 , Ali Omer Qadir 92 , Seema Qayyum 18 , Jiang Qian 93 , BoonLong Quah 81 , Ardizal Rahman 94 , Purnima Rajkarnikar 65 , Rajesh Ramanjulu 70 , Riffat Rashid 83 , Duangnate Rojanaporn 11 , Soma Rani Roy 89 , Raya Hamad Saab 95 , Svetlana Saakyan 88 , Ahmed Hatem Sabhan 3 , Rohit Saiju 76 , Phayvanh Sayalith 68 , Ahad Sedaghat 96 , Rachna Seth 97 , Shawkat Ara Shakoor 98 , Manoj Kumar Sharma 99 , Sorath Noorani Siddiqui 61 , Usha Singh 100 , Penny Singha 46 , Rita S Sitorus 101 , Hendrian D Soebagjo 78 , Sadia Sultana 102 , Xiantao Sun 103 , Eddy Supriyadi 30 , Supawan Surukrattanaskul 104 , Shigenobu Suzuki 105 , Deborah Tan 106 , Jing Tang 7 , Maryam Tashvighi 81 , Kok Hoi Teh 60 , Edi Setiawan Tehuteru 107 , Abdullah Dahan M Thawaba 25 , Helen Toledano 108 , Doan Le Trang 109 , Devjyoti Tripathy 110 , Samuray Tuncer 111 , Emel Unal 112 , Tatiana L Ushakova 91 , Rustam Usmanov 64 , Nishant Verma 58 , Andi Arus Victor 101 , Victoria Vishnevskia-Dai 8 , Yi-Zhuo Wang 113 , Nutsuchar Wangtiraumnuay 104 , Widiarti Pandu Riono 107 , Atchareeya Wiwatwongwana 114 , Damrong Wiwatwongwana 114 , Emily S Wong 115 , Phanthipha Wongwai 116 , Si-Qi Wu 117 , Daoman Xiang 44 , Yishuang Xiao 117 , Bing Xu 75 , Kang Xue 93 , Jason C Yam 115 , Huasheng Yang 118 , Muhammad Amer Yaqub 65 , Vera A Yarovaya 119 , Andrey A Yarovoy 119 , Huijing Ye 118 , Yacoub Abdallah Yousef 84 , Putu Yuliawati 31 , Yi Zhang 113 , Nida Zia 59 , Marcia Zondervan 31 , Ido Didi Fabian 120
Affiliations
- 1 The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Hyderabad, India. Electronic address: kalikiswathi@yahoo.com.
- 2 The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Hyderabad, India.
- 3 Pediatric Oncology Unit, Children Welfare Teaching Hospital, Medical City, College of Medicine, University of Baghdad, Bagdad, Iraq.
- 4 International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Department of Ophthalmology, Great Ormond Street Children's Hospital, London, United Kingdom.
- 5 Ocular Oncology Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
- 6 Department of Ophthalmology, The Indus Hospital, Karachi, Pakistan.
- 7 Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- 8 Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.
- 9 Department of Pediatric Hematology-Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey.
- 10 Department of Ophthalmology, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
- 11 Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
- 12 Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
- 13 Department of Ophthalmology, King Hussein Cancer Center, Amman, Jordan.
- 14 International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.
- 15 The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, India.
- 16 Basra Children Specialty Hospital, Basra, Iraq.
- 17 Department of Pediatrics, Banaras Hindu University, Varanasi, India.
- 18 The Children' Hospital & the Institute of Child Health, Lahore, Pakistan.
- 19 RS Dr. Wahidin Sudirohusodo, Makassar, Indonesia.
- 20 King Khalid eye specialist hospital, Riyadh, Saudi Arabia.
- 21 Hawler Medical University, Erbil, Iraq.
- 22 University of the Philippines - Philippine General Hospital, Manila, Philippines.
- 23 College of Medicine, King Saud University, Riyadh, Saudi Arabia.
- 24 Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon.
- 25 Pediatric Oncology Department, National Oncology Center, Sana'a, Yemen.
- 26 Imam Hussein Cancer Center, Kerbala, Iraq.
- 27 Ibn AlHaitham Teaching Eye Hospital, Baghdad, Iraq.
- 28 Oncology Unit, Child's Central Teaching Hospital, Baghdad, Iraq.
- 29 National Eye Center-Cicendo Eye Hospital, Bandung, Indonesia.
- 30 Sardjito Hospital-Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
- 31 International Centre for Eye Health London School of Hygiene & Tropical Medicine, London, UK.
- 32 Gazi University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
- 33 Ege University, School of Medicine, Division of Pediatric Oncology, Izmir, Turkey.
- 34 Siriraj Hospital Mahidol University, Bangkok, Thailand.
- 35 Zarifa Aliyeva National Centre of Ophthalmology, Baku, Azerbaijan.
- 36 National Center of Oncology and Hematology, Bishkek, Kyrgyzstan.
- 37 Susrut Eye Foundation & Research Institute, Kolkata, India.
- 38 Department of Pediatric Hematology and Oncology, Narayana Health City, Bangalore, India.
- 39 Department of Pediatric Hematology Oncology, Tata Medical Center, Kolkata, India.
- 40 Tel Aviv Sourasky Medical Center and The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
- 41 International Centre for Eye Health London School of Hygiene & Tropical Medicine, London, UK; Ophthalmology Department, Great Ormond Street Children's Hospital, London, UK.
- 42 Pediatric Oncology, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.
- 43 Paediatric Ophthalmology Department, Mayo Hospital & College of Allied Visual Sciences (COAVS), King Edward Medical University, Lahore, Pakistan.
- 44 Department of Pediatric Ophthalmology, Guangzhou Children's Hospital and Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
- 45 National Center for Maternal and Children Health of Mongolia, Ulaanbaatar, Mongolia.
- 46 Department of Ophthalmology, Songklanagarind Hospital, Prince of a Songkla university, Songkla, Thailand.
- 47 The Calcutta Medical Research Institute, Kolkata, India.
- 48 Ocular Oncology Services, Dr Shroff's Charity Eye Hospital, New Delhi, India.
- 49 Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
- 50 Departement of Opthalmology Udayana University, Sanglah Eye Hospital, Bali, Indonesia.
- 51 Aga Khan University, Karachi, Pakistan.
- 52 Pediatric Growth and Development Research Center, Institute of Endocrinology, Iran University of Medical Sciences, Rasool Akram Hospital, Tehran, Iran.
- 53 Hadassah Hebrew University Medical Center, Jerusalem, Israel.
- 54 Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
- 55 National Cancer Institute, Maharagama, Sri Lanka.
- 56 Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
- 57 Bai Jerbai Wadia Hospital for Children, Mumbai, India.
- 58 King George's Medical University, Lucknow, Uttar Pradesh, India.
- 59 The Indus Hospital, Karachi, Pakistan.
- 60 Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
- 61 Department of Pediatric Ophthalmology and Strabismus, Al Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
- 62 Department of pediatrics Faculty of medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
- 63 Oncology Unit, Child Central Teaching Hospital, Baghdad, Iraq.
- 64 National Cancer Center of Uzbekistan, Tashkent, Uzbekistan.
- 65 Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
- 66 Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 67 Istanbul University, Oncology Institute, Pediatric Hematology-Oncology, Istanbul, Turkey.
- 68 Mahosot Hospital, Vientiane, Laos.
- 69 Dhaka Medical College Hospital, Dhaka, Bangladesh.
- 70 Department of Ophthalmology, Post Graduate Medical Institute, Ameer Ud Din Medical College, Lahore General Hospital, Lahore, Pakistan.
- 71 Sankara Nethralaya, Chennai, India.
- 72 Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea.
- 73 Ocular Oncology Service, Hacettepe University School of Medicine, Ankara, Turkey.
- 74 Vitreo-Retina Research Unit, Department of Ophthalmology, Chulalongkorn University, Bangkok, Thailand.
- 75 The first hospital of Dali University, Yunnan Province, China.
- 76 Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
- 77 Chang Gung Memorial Hospital, Taipei, Taiwan.
- 78 Ophthalmology Department, Airlangga University - Dr. Soetomo General Hospital, Surabaya, Indonesia.
- 79 Pediatric Hematology-Oncology Unit, Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, New Delhi, India.
- 80 Scientific Centre for Pediatrics and Pediatric Surgery, Almaty, Kazakhstan.
- 81 Mahak childrens Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Tehran, Iran.
- 82 Centre for Sight, New Delhi, India.
- 83 Sankara Eye Hospital, Bangalore, India.
- 84 King Hussein Cancer Center, Amman, Jordan.
- 85 Aditya Jyot Eye Hospital, Mumbai, India; Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, India.
- 86 Aditya Jyot Eye Hospital, Mumbai, India.
- 87 Child Health Department, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
- 88 Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia.
- 89 Chittagong Eye Infirmary & Training Complex, Chittagong, Bangladesh.
- 90 Yerevan State Medical University, Department of Oncology and Pediatric Cancer and Blood Disorders Center of Armenia, Hematology Center after R.H. Yeolyan, Yerevan, Armenia.
- 91 Head and Neck Tumors Department, SRI of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Center of Oncology of Russian Federation, and Medical Academy of Postgraduate Education, Moscow, Russia.
- 92 Hiwa Cancer Hospital, Al Sulaimaniyah, Iraq.
- 93 Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
- 94 Ophthalmology Department, Dr. M. Djamil General Hospital, Medical Faculty Andalas University West Sumatra, Indonesia.
- 95 Children's Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon.
- 96 Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
- 97 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
- 98 National Institute of Ophthalmology, Dhaka, Bangladesh.
- 99 East Timor Eye Program, Dili, Timor-Leste.
- 100 Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
- 101 Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
- 102 Department of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.
- 103 Henan Children's Hospital, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, China.
- 104 Queen Sirikit National Institute of Child Health, Bangkok, Thailand.
- 105 Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Japan.
- 106 Singapore National Eye Centre and KK Women's and Children's Hospital in Singapore, Singapore.
- 107 National Cancer Center - "Dharmais" Cancer Hospital, Jakarta, Indonesia.
- 108 Department of Pediatric HematologyOncology, Schneider Children's Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.
- 109 Vietnam National Institute of Ophthalmology, Ha Noi, Vietnam.
- 110 LV Prasad Eye Institute, MTC Campus, Bhubaneswar, Odisha, India.
- 111 Istanbul University, Faculty of Medicine, Department of Ophthalmology, Ocular Oncology Service, Istanbul, Turkey.
- 112 Ankara University Department of Pediatrics, Division of Pediatric Hematology-Oncology, Ankara, Turkey.
- 113 Department of Paediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
- 114 Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand.
- 115 Hong Kong Eye Hospital, Chinese University of Hong Kong, Hong Kong, Hong Kong S.A.R.
- 116 Department of ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
- 117 Kunming Children's Hospital, Kunming, China.
- 118 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
- 119 S.Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russia.
- 120 International Centre for Eye Health London School of Hygiene & Tropical Medicine, London, UK; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.
- PMID: 37839559
- DOI: 10.1016/j.ophtha.2023.10.015
Item in Clipboard
Display options
Format
Abstract
Purpose: To describe the clinical presentation and treatment outcomes of children who received a diagnosis of retinoblastoma in 2017 throughout Asia.
Design: Multinational, prospective study including treatment-naïve patients in Asia who received a diagnosis of retinoblastoma in 2017 and were followed up thereafter.
Participants: A total of 2112 patients (2797 eyes) from 96 retinoblastoma treatment centers in 33 Asian countries.
Interventions: Chemotherapy, radiotherapy, enucleation, and orbital exenteration.
Main outcome measures: Enucleation and death.
Results: Within the cohort, 1021 patients (48%) were from South Asia (SA), 503 patients (24%) were from East Asia (EA), 310 patients (15%) were from Southeast Asia (SEA), 218 patients (10%) were from West Asia (WA), and 60 patients (3%) were from Central Asia (CA). Mean age at presentation was 27 months (median, 23 months; range, < 1-261 months). The cohort included 1195 male patients (57%) and 917 female patients (43%). The most common presenting symptoms were leukocoria (72%) and strabismus (13%). Using the American Joint Committee on Cancer Staging Manual, Eighth Edition, classification, tumors were staged as cT1 (n = 441 [16%]), cT2 (n = 951 [34%]), cT3 (n = 1136 [41%]), cT4 (n = 267 [10%]), N1 (n = 48 [2%]), and M1 (n = 129 [6%]) at presentation. Retinoblastoma was treated with intravenous chemotherapy in 1450 eyes (52%) and 857 eyes (31%) underwent primary enucleation. Three-year Kaplan-Meier estimates for enucleation and death were 33% and 13% for CA, 18% and 4% for EA, 27% and 15% for SA, 32% and 22% for SEA, and 20% and 11% for WA (P < 0.0001 and P < 0.0001), respectively.
Conclusions: At the conclusion of this study, significant heterogeneity was found in treatment outcomes of retinoblastoma among the regions of Asia. East Asia displayed better outcomes with higher rates of globe and life salvage, whereas Southeast Asia showed poorer outcomes compared with the rest of Asia.
Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Keywords: Asia; Eye; Retinoblastoma; Tumor.
Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
MeSH terms
LinkOut - more resources
Full Text Sources
