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Comment
. 2023 Oct 16;8(1):388.
doi: 10.1038/s41392-023-01633-y.

Activated STING: an ion channel to trigger non-interferon-related functions

Zhengyu Gao #  1   2 , Bin Wang #  1   2 , Long Zhang  3   4
Affiliations
Comment

Activated STING: an ion channel to trigger non-interferon-related functions

Zhengyu Gao et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The functional model of activated STING as an ion channel. Upon activation, the STING protein translocates to the Golgi apparatus, forming a channel within the transmembrane region. This channel facilitates the efflux of protons, ultimately resulting in the induction of inflammasome activation and LC3B lipidation
See this image and copyright information in PMC

Comment on

  • Human STING is a proton channel.
    Liu B, Carlson RJ, Pires IS, Gentili M, Feng E, Hellier Q, Schwartz MA, Blainey PC, Irvine DJ, Hacohen N. Liu B, et al. Science. 2023 Aug 4;381(6657):508-514. doi: 10.1126/science.adf8974. Epub 2023 Aug 3. Science. 2023. PMID: 37535724 Free PMC article.

References

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    1. Fischer TD, et al. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain. J. Cell Biol. 2020;219:e202009128. doi: 10.1083/jcb.202009128. - DOI - PMC - PubMed
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