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Review
. 2023 Dec;50(12):10383-10398.
doi: 10.1007/s11033-023-08879-3. Epub 2023 Oct 15.

Involvement of CCCTC-binding factor in epigenetic regulation of cancer

Sayani Bose  1 , Srawsta Saha  1 , Harsita Goswami  1 , Geetha Shanmugam  1 , Koustav Sarkar  2
Affiliations
Review

Involvement of CCCTC-binding factor in epigenetic regulation of cancer

Sayani Bose et al. Mol Biol Rep. 2023 Dec.

Abstract

A major global health burden continues to be borne by the complex and multifaceted disease of cancer. Epigenetic changes, which are essential for the emergence and spread of cancer, have drawn a huge amount of attention recently. The CCCTC-binding factor (CTCF), which takes part in a wide range of cellular processes including genomic imprinting, X chromosome inactivation, 3D chromatin architecture, local modifications of histone, and RNA polymerase II-mediated gene transcription, stands out among the diverse array of epigenetic regulators. CTCF not only functions as an architectural protein but also modulates DNA methylation and histone modifications. Epigenetic regulation of cancer has already been the focus of plenty of studies. Understanding the role of CTCF in the cancer epigenetic landscape may lead to the development of novel targeted therapeutic strategies for cancer. CTCF has already earned its status as a tumor suppressor gene by acting like a homeostatic regulator of genome integrity and function. Moreover, CTCF has a direct effect on many important transcriptional regulators that control the cell cycle, apoptosis, senescence, and differentiation. As we learn more about CTCF-mediated epigenetic modifications and transcriptional regulations, the possibility of utilizing CTCF as a diagnostic marker and therapeutic target for cancer will also increase. Thus, the current review intends to promote personalized and precision-based therapeutics for cancer patients by shedding light on the complex interplay between CTCF and epigenetic processes.

Keywords: CTCF; Cancer; Epigenetic regulation; Signaling pathways; Transcriptional aviator or repressor.

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