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Review
. 2023 Sep 29:14:1206959.
doi: 10.3389/fimmu.2023.1206959. eCollection 2023.

Advances in pathogenesis and treatment of ocular involvement in Behcet's disease

Suibin Lin  1 , Zhirong Xu  2 , Zhiming Lin  3 , Baozhao Xie  4 , Junmei Feng  5   6
Affiliations
Review

Advances in pathogenesis and treatment of ocular involvement in Behcet's disease

Suibin Lin et al. Front Immunol. .

Abstract

Behcet's disease (BD) is a chronic multi-systemic disease characterized by relapsing-remitting oral ulcers, genital ulcers, ocular inflammatory involvements, and numerous other systemic features. Ocular involvements are quite common in BD and may cause severe tissue damage and potentially blindness. Even though the pathogenesis of BD remains ambiguous, growing evidences have shown that genetic factors, environmental triggers and immunological abnormalities play significant roles in its development and progression. Novel biotherapies targeting IFN-γ, TNF-α and interleukins have been used in recent years. In this review, we mainly pay attention to the ocular involvement of BD, and discuss the current understanding of mechanisms and advances in therapeutic approaches, especially novel biologics. Finally, we discuss the management in patients with pregnancy.

Keywords: Behcet’s disease; Behcet’s uveitis; biological agent; immunogenetic; immunopathogenesis; ocular involvement; pregnancy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor WS declared a shared parent affiliation with the author ZL at the time of review.

Figures

Figure 1
Figure 1
The role of T cells in the pathogenesis of Behcets disease and eye inflammation.
See this image and copyright information in PMC

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