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Review
. 2023 Sep 29:14:1257988.
doi: 10.3389/fimmu.2023.1257988. eCollection 2023.

Research progress of NF-κB signaling pathway and thrombosis

Zilong Wang  1 , Chucun Fang  1 , Mengting Yao  1 , Dongwen Wu  1 , Maga Chen  1 , Tianting Guo  2 , Jianwen Mo  3
Affiliations
Review

Research progress of NF-κB signaling pathway and thrombosis

Zilong Wang et al. Front Immunol. .

Abstract

Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes from venous thrombosis, which is the most serious cause of death, second only to ischemic heart disease and stroke patients. It can be seen that deep-vein thrombosis has become a serious disease affecting human health. In recent years, with the deepening of research, inflammatory response is considered to be an important pathway to trigger venous thromboembolism, in which the transcription factor NF-κB is the central medium of inflammation, and the NF-κB signaling pathway can regulate the pro-inflammatory and coagulation response. Thus, to explore the mechanism and make use of it may provide new solutions for the prevention and treatment of thrombosis.

Keywords: NF-κB signal pathway; TCM; drugs; inflammation; miRNA; natural compounds; thrombosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Summary of NF-κB pathway mediating inflammation and thrombosis (by Figdraw, authorization ID: PIWYI6b557).
See this image and copyright information in PMC

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