Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 29:14:1257988.
doi: 10.3389/fimmu.2023.1257988. eCollection 2023.

Research progress of NF-κB signaling pathway and thrombosis

Zilong Wang  1 , Chucun Fang  1 , Mengting Yao  1 , Dongwen Wu  1 , Maga Chen  1 , Tianting Guo  2 , Jianwen Mo  3
Affiliations
Review

Research progress of NF-κB signaling pathway and thrombosis

Zilong Wang et al. Front Immunol. .

Abstract

Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes from venous thrombosis, which is the most serious cause of death, second only to ischemic heart disease and stroke patients. It can be seen that deep-vein thrombosis has become a serious disease affecting human health. In recent years, with the deepening of research, inflammatory response is considered to be an important pathway to trigger venous thromboembolism, in which the transcription factor NF-κB is the central medium of inflammation, and the NF-κB signaling pathway can regulate the pro-inflammatory and coagulation response. Thus, to explore the mechanism and make use of it may provide new solutions for the prevention and treatment of thrombosis.

Keywords: NF-κB signal pathway; TCM; drugs; inflammation; miRNA; natural compounds; thrombosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Summary of NF-κB pathway mediating inflammation and thrombosis (by Figdraw, authorization ID: PIWYI6b557).
See this image and copyright information in PMC

References

    1. Di Nisio M, van Es N, Büller HR. Deep vein thrombosis and pulmonary embolism. Lancet (2016) 388:3060–73. doi: 10.1016/S0140-6736(16)30514-1 - DOI - PubMed
    1. Áinle FN, Kevane B. Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)? Hematol Am Soc Hematol Educ Program (2020) 2020:201–12. doi: 10.1182/hematology.2020002268 - DOI - PMC - PubMed
    1. Tritschler T, Kraaijpoel N, Le Gal G, Wells PS. Venous thromboembolism: advances in diagnosis and treatment. JAMA (2018) 320:1583–94. doi: 10.1001/jama.2018.14346 - DOI - PubMed
    1. Blann AD, Lip GY. Virchow’s triad revisited: the importance of soluble coagulation factors, the endothelium, and platelets. Thromb Res (2001) 101:321–7. doi: 10.1016/s0049-3848(00)00419-9 - DOI - PubMed
    1. Gimbrone MA, García-Cardeña G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol (2013) 22:9–15. doi: 10.1016/j.carpath.2012.06.006 - DOI - PMC - PubMed

Publication types