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. 2023 Sep 28:68:1606328.
doi: 10.3389/ijph.2023.1606328. eCollection 2023.

Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination

Alexandre Vallée  1
Affiliations

Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination

Alexandre Vallée. Int J Public Health. .

Abstract

Objective: The purpose of this study was to investigate the sex correlations of particulate matters (PM2.5, PM10, PM2.5-10), NO2 and NOx with ASCVD risk in the UK Biobank population. Methods: Among 285,045 participants, pollutants were assessed and correlations between ASCVD risk were stratified by sex and estimated using multiple linear and logistic regressions adjusted for length of time at residence, education, income, physical activity, Townsend deprivation, alcohol, smocking pack years, BMI and rural/urban zone. Results: Males presented higher ASCVD risk than females (8.63% vs. 2.65%, p < 0.001). In males PM2.5, PM10, NO2, and NOx each were associated with an increased ASCVD risk >7.5% in the adjusted logistic models, with ORs [95% CI] for a 10 μg/m3 increase were 2.17 [1.87-2.52], 1.15 [1.06-1.24], 1.06 [1.04-1.08] and 1.05 [1.04-1.06], respectively. In females, the ORs for a 10 μg/m3 increase were 1.55 [1.19-2.05], 1.22 [1.06-1.42], 1.07 [1.03-1.10], and 1.04 [1.02-1.05], respectively. No association was observed in both sexes between ASCVD risk and PM2.5-10. Conclusion: Our findings may suggest the possible actions of air pollutants on ASCVD risk.

Keywords: air pollution; atherosclerosis; cardiovascular risk; public health; sex.

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Conflict of interest statement

The author declares that they do not have any conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart (United Kingdom, 2021).
FIGURE 2
FIGURE 2
Non-linear splines of air pollutants with atherosclerotic cardiovascular disease risk (United Kingdom, 2021).
See this image and copyright information in PMC

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References

    1. Cohen AJ, Brauer M, Burnett R, Anderson HR, Frostad J, Estep K, et al. Estimates and 25-Year Trends of the Global Burden of Disease Attributable to Ambient Air Pollution: An Analysis of Data From the Global Burden of Diseases Study 2015. Lancet Lond Engl (2017) 389:1907–18. –1918. 10.1016/S0140-6736(17)30505-6 - DOI - PMC - PubMed
    1. Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, et al. 2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J (2021) 42:3227–337. 10.1093/eurheartj/ehab484 - DOI - PubMed
    1. Kampa M, Castanas E. Human Health Effects of Air Pollution. Environ Pollut Barking Essex (2008) 151:362–7. 10.1016/j.envpol.2007.06.012 - DOI - PubMed
    1. Anderson JO, Thundiyil JG, Stolbach A. Clearing the Air: A Review of the Effects of Particulate Matter Air Pollution on Human Health. J Med Toxicol Off J Am Coll Med Toxicol (2012) 8:166–75. 10.1007/s13181-011-0203-1 - DOI - PMC - PubMed
    1. Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E. Environmental and Health Impacts of Air Pollution: A Review. Front Public Health (2020) 8:14. 10.3389/fpubh.2020.00014 - DOI - PMC - PubMed