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Case Reports
. 2023 Sep 7:41:10-12.
doi: 10.1016/j.jdcr.2023.08.013. eCollection 2023 Nov.

Pemphigoid gestationis treated with dupilumab

Rita E Chen  1 , Christine C Yokoyama  1 , Milan J Anadkat  1
Affiliations
Case Reports

Pemphigoid gestationis treated with dupilumab

Rita E Chen et al. JAAD Case Rep. .
No abstract available

Keywords: corticosteroid-sparing therapy; dupilumab; immunobullous disease; pemphigoid gestationis; pregnancy related rash; pruritus.

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Conflict of interest statement

Dr Anadkat has served as a Consultant and/or Advisor for ImClone, Bristol Myers Squibb, Astra Zeneca, Therakos, Aspire Bariatrics, Biogen, Amgen, Veloce, Adgero, Eli Lilly, Abbvie, UCB Biopharma, Innovaderm, Boehringer-Ingelheim, OnQuality, Novocure, Springworks, BioLinq, and Protagonist. MJA has served as a Principal Investigator for Novartis, Boehringer-Ingelheim, Lutris, OnQuality, UCB Biopharma, InflamRx, Eli Lilly, InCyte, Abbvie, Moonlake, AnaptysBio, Hana Biosciences, Xoma, Veloce, Biogen, Xbiotech, and Chemocentryx. Author Chen and Dr Yokoyama have no conflicts of interest to declare.

Figures

Fig 1
Fig 1
Pemphigoid gestationis rash on presentation. Urticarial plaques on the thigh (A). Vesicular lesions near the umbilicus (B).
Fig 2
Fig 2
Pemphigoid gestationis rash during first pregnancy. Urticarial plaques and vesicles on the thigh.
Fig 3
Fig 3
Pemphigoid gestationis rash after delivery. Urticarial plaques on the thighs.
See this image and copyright information in PMC

References

    1. Fong H., Gandhi G.R., Gharbi A., Hafsi W. StatPearls Publishing LLC; 2022. Pemphigoid Gestationis. StatPearls. - PubMed
    1. Schauer F., Mai S., Hofmann S.C., et al. Autoreactivity to BP180 neoepitopes in patients with pemphigoid gestationis. JAMA Dermatol. 2022;158:212–214. doi: 10.1001/jamadermatol.2021.5294. - DOI - PMC - PubMed
    1. Borthwick G.M., Sunderland C.A., Holmes R.C., Black M.M., Stirrat G.M. Abnormal expression of HLA-DR antigen in the placenta of a patient with pemphigoid gestationis. J Reprod Immunol. 1984;6:393–396. doi: 10.1016/0165-0378(84)90048-2. - DOI - PubMed
    1. Genovese G., Derlino F., Cerri A., et al. A systematic review of treatment options and clinical outcomes in pemphigoid gestationis. Front Med (Lausanne) 2020;7 doi: 10.3389/fmed.2020.604945. - DOI - PMC - PubMed
    1. Abdat R., Waldman R.A., de Bedout V., et al. Dupilumab as a novel therapy for bullous pemphigoid: a multicenter case series. J Am Acad Dermatol. 2020;83:46–52. doi: 10.1016/j.jaad.2020.01.089. - DOI - PubMed

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