Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 29:14:1266728.
doi: 10.3389/fendo.2023.1266728. eCollection 2023.

Cardiovascular and metabolic status in patients with primary hyperparathyroidism: a single-center experience

Ekaterina A Dobreva  1 , Anna M Gorbacheva  1 , Ekaterina E Bibik  1 , Anna K Eremkina  1 , Alina R Elfimova  1 , Rustam Kh Salimkhanov  1 , Elena V Kovaleva  1 , Irina S Maganeva  1 , Natalia G Mokrysheva  2
Affiliations

Cardiovascular and metabolic status in patients with primary hyperparathyroidism: a single-center experience

Ekaterina A Dobreva et al. Front Endocrinol (Lausanne). .

Abstract

Introduction: Cardiovascular diseases (CVD) and metabolic disorders (MD) have retained leading positions in the structure of morbidity and mortality for many years. Primary hyperparathyroidism (PHPT) is also associated with a greater incidence of CVD and MD. The aim of the present study was to describe the prevalence and structure of CVD and MD in hospitalized patients with PHPT and to search for possible associations between these pathologies.

Methods: 838 patients with a verified PHPT were included in the study. The studied cohort was divided into 2 groups according to their age at the time of admission: patients aged 18 to 49 years (group A, n = 150); patients aged 50 years and older (group B, n = 688).

Results: There were no significant differences between two groups in parameters of calcium-phosphorus metabolism. Obesity was diagnosed in 24.2% of patients in group A and in 35.9% in group B. Type 2 diabetes mellitus was more common in older patients (14.4% in group B vs. 2.6% in group A). Arterial hypertension, ischemic heart disease, chronic heart failure and brachiocephalic arteries atherosclerosis were more frequent in older patients, occurring in 79.1%, 10.8%, 8.4%, and 84% of cases respectively. The cutoff points that increased the risk of CVD detection turned out to be age above 56 years, eGFR below 92 ml/min/1.73m2, BMI above 28.3 kg/m2.

Discussion: The present study demonstrated a high incidence of some CVD, as well as disorders of lipid, carbohydrate and purine metabolism in patients with PHPT.

Keywords: arterial hypertension; cardiovascular diseases; diabetes mellitus; dyslipidemia; metabolic diseases; primary hyperparathyroidism.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
ROC analysis for: (A) — age; (B) — eGFR; (C) — BMI to determine increased probability of CVDs in patients with PHPT.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Vestergaard P, Mollerup CL, Frøkjaer VG, Christiansen P, Blichert-Toft M, Mosekilde L. Cardiovascular events before and after surgery for primary hyperparathyroidism. World J Surg (2003) 27(2):216–22. doi: 10.1007/s00268-002-6541-z - DOI - PubMed
    1. Cardenas MG, Vigil KJ, Talpos GB, Lee MW, Peterson E, Rao DS. Prevalence of type 2 diabetes mellitus in patients with primary hyperparathyroidism. Endocr Pract (2008) 14(1):69–75. doi: 10.4158/EP.14.1.69 - DOI - PubMed
    1. Kumari P, Arya AK, Pal R, Sood A, Dahiya D, Mukherjee S, et al. . Comparison of profile of primary hyperparathyroidism with and without type 2 diabetes mellitus: Retrospective analysis from the Indian primary hyperparathyroidism registry. Endocr Pract (2022) 28(1):96–101. doi: 10.1016/j.eprac.2021.09.012 - DOI - PubMed
    1. Bilezikian JP, Khan AA, Silverberg SJ, Fuleihan GEH, Marcocci C, Minisola S, et al. . Evaluation and management of primary hyperparathyroidism: Summary statement and guidelines from the fifth international workshop. J Bone Mineral Res (2022) 37(11):2293–314. doi: 10.1002/jbmr.4677 - DOI - PubMed
    1. Pepe J, Cipriani C, Sonato C, Raimo O, Biamonte F, Minisola S. Cardiovascular manifestations of primary hyperparathyroidism: a narrative review. Eur J Endocrinol (2017) 177(6):R297–308. doi: 10.1530/EJE-17-0485 - DOI - PubMed

MeSH terms