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. 2023 Oct 9:15:367-374.
doi: 10.2147/JEP.S427615. eCollection 2023.

The Efficacy of Topical Formulation Containing Ciplukan (Physalis angulata Linn.) in Modulating Interleukin-17 and Interferon Gamma Expression in Mice (Mus musculus) Psoriasis Model

Oki Suwarsa  1 , Hartati Purbo Dharmadji  1 , Enny Rohmawaty  2 , Shela Mareta  1 , Hendra Gunawan  1 , Reiva Farah Dwiyana  1 , Pati Aji Achdiat  1 , Endang Sutedja  1 , Miranti Pangastuti  1
Affiliations

The Efficacy of Topical Formulation Containing Ciplukan (Physalis angulata Linn.) in Modulating Interleukin-17 and Interferon Gamma Expression in Mice (Mus musculus) Psoriasis Model

Oki Suwarsa et al. J Exp Pharmacol. .

Abstract

Background: Interleukin 17 (IL-17) and interferon gamma (IFN-γ) play a role in the pathogenesis of psoriasis vulgaris (PV). Topical corticosteroids are still utilised as first-line therapy for mild to moderate PV. However, long-term use of corticosteroid is associated with various side effects. Physalis angulata Linn. (Ciplukan) possesses anti-inflammatory properties that could serve as a potential alternative topical therapy for PV.

Objective: To assess the efficacy of topical ciplukan as an anti-inflammatory agent targeting the expression of IL-17 and IFN-γ.

Methods: Psoriasis was induced using imiquimod cream, therefore divided into five groups. Group I, the psoriasis control group, received only imiquimod cream. Groups C1 and C2 received imiquimod cream followed by a mixture of Ciplukan and vaseline in a 1:2 and 1:4 ratio, respectively. Group M, the standard therapy group, received imiquimod cream, followed by mometasone furoate cream. Lastly, group V, the vehicle group, received imiquimod cream followed by vaseline album. Expression of IL-17 and IFN-γ in mice's skin tissue was analysed using reverse transcription polymerase chain reaction (RT-PCR) after seven days of treatment.

Results: The mean expression of IL-17 in Group C1 (22.60) was significantly lower (p = 0.012) than in the psoriasis control group (23.60), and there was no significant difference (p = 0.613) in Group M (22.41). The mean expression of IFN-γ in Group C1 (26.97) and Group C2 (27.03) was also significantly lower (p = 0.026 and p = 0.026, respectively) than Group I (28.80), and there was no significant difference (p = 0.180 and p = 0.093, respectively) than Group M (26.03).

Conclusion: Expression of IL-17 and IFN-γ in the ciplukan group is lower than in the psoriasis control group, and there is no significant difference compared to the standard therapy group.

Keywords: IFN-γ; IL-17; Physalis angulata Linn; psoriasis vulgaris.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Clinical image of skin lesion after treatment. (a) Group I, psoriasis control group (5% imiquimod cream), Modified PASI 6. (b) Group C1 (5% imiquimod cream followed by a mixture of Ciplukan and vaseline in a 1:2 ratio), Modified PASI 1. (c) Group C2 (5% imiquimod cream followed by a mixture of Ciplukan and vaseline in a 1:4 ratio), Modified PASI 1. (d) Group M (5% imiquimod cream followed by mometasone furoate cream), Modified PASI 1. (e) Group V, vehicle group (5% imiquimod cream followed by vaselin album), Modified PASI 4.
See this image and copyright information in PMC

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