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Review
. 2023 Oct 4;9(10):e20636.
doi: 10.1016/j.heliyon.2023.e20636. eCollection 2023 Oct.

Role of pattern recognition receptors in sensing Mycobacterium tuberculosis

S M Neamul Kabir Zihad  1 , Nazifa Sifat  2 , Mohammad Ashraful Islam  3 , A S M Monjur-Al-Hossain  4 , K M Yasif Kayes Sikdar  4 , Md Moklesur Rahman Sarker  1   5 , Jamil A Shilpi  6 , Shaikh Jamal Uddin  6
Affiliations
Review

Role of pattern recognition receptors in sensing Mycobacterium tuberculosis

S M Neamul Kabir Zihad et al. Heliyon. .

Abstract

Mycobacterium tuberculosis is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis. Host immune cells not only mount the protective action against this pathogen but also serve as the primary niche for growth. Thus, recognition of this pathogen by host immune cells and following signaling cascades are key dictators of the disease state. Immune cells, mainly belonging to myeloid cell lineage, recognize a wide variety of Mycobacterium tuberculosis ligands ranging from carbohydrate and lipids to proteins to nucleic acids by different membrane-bound and soluble pattern recognition receptors. Simultaneous interaction between different host receptors and pathogen ligands leads to immune-inflammatory response as well as contributes to virulence. This review summarizes the contribution of pattern recognition receptors of host immune cells in recognizing Mycobacterium tuberculosis and subsequent initiation of signaling pathways to provide the molecular insight of the specific Mtb ligands interacting with specific PRR, key adaptor molecules of the downstream signaling pathways and the resultant effector functions which will aid in identifying novel drug targets, and developing novel drugs and adjuvants.

Keywords: Cytokines; Inflammasome; Mycobacterium tuberculosis; Pattern recognition receptor; Phagocytosis.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Major immune signaling pathways following recognition of Mtb PAMPs by host PRRs.
See this image and copyright information in PMC

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