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. 1979 Mar;3(2):113-9.
doi: 10.1016/0309-1651(79)90115-2.

Effect of intracellular injection of La3+ and Mn2+ on electrical coupling of heart cells

W C De Mello

Effect of intracellular injection of La3+ and Mn2+ on electrical coupling of heart cells

W C De Mello. Cell Biol Int Rep. 1979 Mar.

Abstract

The effect of intracellular injection of La3+ and Mn2+ on the electrical coupling of canine Purkinje cells investigated. It was found that La3+ causes cell decoupling in about 100 sec, increased the input resistance of the injected cell too. Mn2+ injection reduced drastically the coupling coefficient but did not abolish cell communication. Intracellular injection of La3+ or Mn2+ also caused shortening of the action potential and hyperpolarized the the heart cells. La3+ seems to be as effective as Ca or even stronger than Ca in suppressing intercellular communication in heart fibres.

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