Effect of intracellular injection of La3+ and Mn2+ on electrical coupling of heart cells
- PMID: 378426
- DOI: 10.1016/0309-1651(79)90115-2
Effect of intracellular injection of La3+ and Mn2+ on electrical coupling of heart cells
Abstract
The effect of intracellular injection of La3+ and Mn2+ on the electrical coupling of canine Purkinje cells investigated. It was found that La3+ causes cell decoupling in about 100 sec, increased the input resistance of the injected cell too. Mn2+ injection reduced drastically the coupling coefficient but did not abolish cell communication. Intracellular injection of La3+ or Mn2+ also caused shortening of the action potential and hyperpolarized the the heart cells. La3+ seems to be as effective as Ca or even stronger than Ca in suppressing intercellular communication in heart fibres.
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