Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 30;12(11):581-585.
doi: 10.1093/jpids/piad088.

First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

Chishala Chabala  1   2   3 , Tom G Jacobs  4 , Cinta Moraleda  5 , John M Ndaferankhande  6 , Vivian Mumbiro  7 , Alfeu Passanduca  8 , Natasha Namuziya  2 , Damalie Nalwanga  9 , Victor Musiime  9   10 , Alvaro Ballesteros  5 , Sara Domínguez-Rodríguez  5 , Moses Chitsamatanga  7 , Uneisse Cassia  8 , Bwendo Nduna  11 , Justina Bramugy  12 , Jahit Sacarlal  8 , Lola Madrid  5   13 , Kusum J Nathoo  7 , Angela Colbers  4 , David M Burger  4 , Veronica Mulenga  1   2 , W Chris Buck  8   14 , Hilda A Mujuru  7 , Lindsey H M Te Brake  4 , Pablo Rojo  5   15   16 , Alfredo Tagarro  5   17   18 , Rob E Aarnoutse  4 ; EMPIRICAL clinical trial group
Collaborators, Affiliations

First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

Chishala Chabala et al. J Pediatric Infect Dis Soc. .

Abstract

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

Keywords: HIV; HRZE; Tuberculosis; infants; pharmacokinetics.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Individual TB drug concentrations on study visit day 30 at 2 hours after dose administration (C2h). The grey solid lines represent the geometric means of the individual C2h, the grey dotted lines represent the adult target Cmax ranges as reported by Alsultan et al. [9], and the black dashed lines represent the median Cmax for children within the 4-7.9 kg weight-band as reported by Chabala et al. [5]. Top left panel: isoniazid; top right panel: rifampicin; bottom left panel: pyrazinamide; bottom right panel: ethambutol.
See this image and copyright information in PMC

References

    1. UNAIDS. UNAIDS Data 2022. Geneva, Switzerland: Geneva Joint United Nations Programme on HIV/AIDS; 2022.
    1. Marais BJ, Gie RP, Schaaf HS, et al. . The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 2004; 8:392–402. - PubMed
    1. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE.. Developmental pharmacology--drug disposition, action, and therapy in infants and children. N Engl J Med 2003; 349:1157–67. - PubMed
    1. Kwara A, Yang H, Martyn-Dickens C, et al. . Adequacy of WHO weight-band dosing and fixed-dose combinations for the treatment of TB in children. Int J Tuberc Lung Dis 2023; 27:401–7. - PubMed
    1. Chabala C, Turkova A, Hesseling AC, et al. . Pharmacokinetics of first-line drugs in children with Tuberculosis, using World Health Organization-recommended weight band doses and formulations. Clin Infect Dis 2022; 74:1767–75. - PMC - PubMed

Substances