Cardiac 18F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

doi:10.1007/s10286-023-00987-1

Review

. 2023 Dec;33(6):737-747.

doi: 10.1007/s10286-023-00987-1. Epub 2023 Oct 16.

Cardiac ¹⁸F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

Abhishek Lenka^{1

2}, Risa Isonaka¹, Courtney Holmes¹, David S Goldstein³

Affiliations

¹ Autonomic Medicine Section, National Institute of Neurological, Disorders and Stroke (NINDS), National Institutes of Health (NIH), CNP/DIR/NINDS/NIH, 9000 Rockville Pike MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892, USA.
² Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
³ Autonomic Medicine Section, National Institute of Neurological, Disorders and Stroke (NINDS), National Institutes of Health (NIH), CNP/DIR/NINDS/NIH, 9000 Rockville Pike MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892, USA. goldsteind@ninds.nih.gov.

PMID: 37843677
DOI: 10.1007/s10286-023-00987-1

Review

Cardiac ¹⁸F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

Abhishek Lenka et al. Clin Auton Res. 2023 Dec.

. 2023 Dec;33(6):737-747.

doi: 10.1007/s10286-023-00987-1. Epub 2023 Oct 16.

Authors

Abhishek Lenka^{1

2}, Risa Isonaka¹, Courtney Holmes¹, David S Goldstein³

Affiliations

¹ Autonomic Medicine Section, National Institute of Neurological, Disorders and Stroke (NINDS), National Institutes of Health (NIH), CNP/DIR/NINDS/NIH, 9000 Rockville Pike MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892, USA.
² Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
³ Autonomic Medicine Section, National Institute of Neurological, Disorders and Stroke (NINDS), National Institutes of Health (NIH), CNP/DIR/NINDS/NIH, 9000 Rockville Pike MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892, USA. goldsteind@ninds.nih.gov.

PMID: 37843677
DOI: 10.1007/s10286-023-00987-1

Abstract

Purpose: Pure autonomic failure (PAF) is a rare disease characterized by neurogenic orthostatic hypotension (nOH), no known secondary cause, and lack of a neurodegenerative movement or cognitive disorder. Clinically diagnosed PAF can evolve ("phenoconvert") to a central Lewy body disease [LBD, e.g., Parkinson's disease (PD) or dementia with Lewy bodies (DLB)] or to the non-LBD synucleinopathy multiple system atrophy (MSA). Since cardiac ¹⁸F-dopamine-derived radioactivity usually is low in LBDs and usually is normal in MSA, we hypothesized that patients with PAF with low cardiac ¹⁸F-dopamine-derived radioactivity would be more likely to phenoconvert to a central LBD than to MSA.

Methods: We reviewed data from all the patients seen at the National Institutes of Health Clinical Center from 1994 to 2023 with a clinical diagnosis of PAF and data about ¹⁸F-dopamine positron emission tomography (PET).

Results: Nineteen patients (15 with low ¹⁸F-dopamine-derived radioactivity, 4 with normal radioactivity) met the above criteria and had follow-up data. Nine (47%) phenoconverted to a central synucleinopathy over a mean of 6.6 years (range 1.5-18.8 years). All 6 patients with low cardiac ¹⁸F-dopamine-derived radioactivity who phenoconverted during follow-up developed a central LBD, whereas none of 4 patients with consistently normal ¹⁸F-dopamine PET phenoconverted to a central LBD (p = 0.0048), 3 evolving to probable MSA and 1 upon autopsy having neither a LBD nor MSA.

Conclusion: Cardiac ¹⁸F-dopamine PET can predict the type of phenoconversion of PAF. This capability could refine eligibility criteria for entry into disease-modification trials aimed at preventing evolution of PAF to symptomatic central LBDs.

Keywords: Dementia with Lewy bodies; Fluorodopamine; Multiple system atrophy; Parkinson’s disease; Pure autonomic failure.

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Update of

Cardiac 18F-Dopamine Positron Emission Tomography Predicts the Type of Phenoconversion of Pure Autonomic Failure.
Lenka A, Isonaka R, Holmes C, Goldstein DS. Lenka A, et al. Res Sq [Preprint]. 2023 Jul 17:rs.3.rs-3157807. doi: 10.21203/rs.3.rs-3157807/v1. Res Sq. 2023. Update in: Clin Auton Res. 2023 Dec;33(6):737-747. doi: 10.1007/s10286-023-00987-1. PMID: 37503103 Free PMC article. Updated. Preprint.

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References

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1. Cook GA, Sullivan P, Holmes C, Goldstein DS (2014) Cardiac sympathetic denervation without lewy bodies in a case of multiple system atrophy. Parkinsonism Relat Disord 20:926–928 - PubMed - PMC - DOI
1. Coon EA, Mandrekar JN, Berini SE, Benarroch EE, Sandroni P, Low PA, Singer W (2020) Predicting phenoconversion in pure autonomic failure. Neurology 95:e889–e897 - PubMed - PMC - DOI
1. de Natale ER, Wilson H, Politis M (2022) Predictors of RBD progression and conversion to synucleinopathies. Curr Neurol Neurosci Rep 22:93–104 - PubMed - PMC - DOI

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[1] Bradbury S, Eggleston C (1925) Postural hypotension: a report of three cases. Am Heart J 1:73–86 - DOI

[2] Bradbury S, Eggleston C (1925) Postural hypotension: a report of three cases. Am Heart J 1:73–86 - DOI

[3] Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner TT, Jaunmuktane Z, Galasko D, Santana I, Tienari PJ, Myllykangas L, Oinas M, Cairns NJ, Morris JC, Halliday GM, Van Deerlin VM, Trojanowski JQ, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Brett F, Gan-Or Z, Geiger JT, Moore A, May P, Kruger R, Goldstein DS, Lopez G, Tayebi N, Sidransky E, American Genome C, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Shakkottai VG, Perkins M, Newell KL, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim RC, Caraway CA, Monuki ES, Brunetti M, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Flanagan ME, Mao Q, Bigio EH, Rodriguez-Rodriguez E, Infante J, Lage C, Gonzalez-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black SE, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett MJ, Tilley BS, Gentleman S, Logroscino G et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet 53:294–303 - PubMed - PMC - DOI

[4] Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner TT, Jaunmuktane Z, Galasko D, Santana I, Tienari PJ, Myllykangas L, Oinas M, Cairns NJ, Morris JC, Halliday GM, Van Deerlin VM, Trojanowski JQ, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Brett F, Gan-Or Z, Geiger JT, Moore A, May P, Kruger R, Goldstein DS, Lopez G, Tayebi N, Sidransky E, American Genome C, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Shakkottai VG, Perkins M, Newell KL, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim RC, Caraway CA, Monuki ES, Brunetti M, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Flanagan ME, Mao Q, Bigio EH, Rodriguez-Rodriguez E, Infante J, Lage C, Gonzalez-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black SE, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett MJ, Tilley BS, Gentleman S, Logroscino G et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet 53:294–303 - PubMed - PMC - DOI

[5] Cook GA, Sullivan P, Holmes C, Goldstein DS (2014) Cardiac sympathetic denervation without lewy bodies in a case of multiple system atrophy. Parkinsonism Relat Disord 20:926–928 - PubMed - PMC - DOI

[6] Cook GA, Sullivan P, Holmes C, Goldstein DS (2014) Cardiac sympathetic denervation without lewy bodies in a case of multiple system atrophy. Parkinsonism Relat Disord 20:926–928 - PubMed - PMC - DOI

[7] Coon EA, Mandrekar JN, Berini SE, Benarroch EE, Sandroni P, Low PA, Singer W (2020) Predicting phenoconversion in pure autonomic failure. Neurology 95:e889–e897 - PubMed - PMC - DOI

[8] Coon EA, Mandrekar JN, Berini SE, Benarroch EE, Sandroni P, Low PA, Singer W (2020) Predicting phenoconversion in pure autonomic failure. Neurology 95:e889–e897 - PubMed - PMC - DOI

[9] de Natale ER, Wilson H, Politis M (2022) Predictors of RBD progression and conversion to synucleinopathies. Curr Neurol Neurosci Rep 22:93–104 - PubMed - PMC - DOI

[10] de Natale ER, Wilson H, Politis M (2022) Predictors of RBD progression and conversion to synucleinopathies. Curr Neurol Neurosci Rep 22:93–104 - PubMed - PMC - DOI

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Cardiac ¹⁸F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

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Cardiac ¹⁸F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

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