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. 2023 Jan-Dec:14:21501319231204436.
doi: 10.1177/21501319231204436.

Prevalence of Upper Respiratory Tract Infections Before, During, and After the COVID-19 Pandemic in Germany: A Cross-Sectional Study of 2 167 453 Outpatients

Sven H Loosen  1 , Wolfgang Plendl  2 , Marcel Konrad  3 , Christian Tanislav  4 , Tom Luedde  1 , Christoph Roderburg  1 , Karel Kostev  2   5
Affiliations

Prevalence of Upper Respiratory Tract Infections Before, During, and After the COVID-19 Pandemic in Germany: A Cross-Sectional Study of 2 167 453 Outpatients

Sven H Loosen et al. J Prim Care Community Health. 2023 Jan-Dec.

Abstract

Background: Although the burden of the COVID-19 pandemic on global healthcare systems is declining, long-term sequelae such as long COVID syndrome and other disease dynamics not primarily associated with COVID-19 remain a challenge. Recent data suggest that the incidence of non-COVID upper respiratory tract infections (URTI) is increasing sharply in the post-pandemic period, but there is a lack of real-world data from Germany in this respect.

Methods: This cross-sectional study evaluated the number of patients with a diagnosis of URTI from the Disease Analyzer database (IQVIA) between January 2019 and December 2022. The number of UTRI diagnoses per practice and the duration of sick leave per patient were compared over time.

Results: A total of 1 872 935 individuals (1 403 907 patients from general practices (GP) and 469 028 patients from pediatric offices) were included, 48% of whom were female. The number of URTI patients per practice was significantly higher in 2022 than in 2019 (732 vs 464, 58%, P < .001), and this was observed for both women (56%, P < .001) and men (60%, P < .001). The post-pandemic increase in the number of URTI diagnoses correlated with age and was highest in the age group between 18 and 30 years (22%, P < .001) and lowest in older patients >70 years (3%). In pediatric patients (<18 years), the increase was highest in the age group ≤5 years (89%). Both the number of patients per practice on sick leave due to URTI (184 vs 92) and the average duration of sick leave (+2 days) increased from 2019 to 2022.

Conclusion: Our data suggest a dramatic increase in the incidence of URTI among all demographic subgroups in Germany between 2019 and 2022, which was associated with a tremendous impact on socioeconomic variables such as the frequency or duration of sick leave. These data could be of great importance in current pandemic management and the management of future pandemics.

Keywords: COVID-19; SARS-CoV-2; URTI; infection; pneumonia; sick leave.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Number of GP patients with upper respiratory tract infections in 2019 to 2022 (total and by sex).
Figure 2.
Figure 2.
Number of GP patients with upper respiratory tract infections in 2019 to 2022 by age group.
Figure 3.
Figure 3.
Number of PP patients with upper respiratory tract infections in 2019 to 2022 total, and by sex and age group.
See this image and copyright information in PMC

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References

    1. Assefa Y, Gilks CF, van de Pas R, Reid S, Gete DG, Van Damme W. Reimagining global health systems for the 21st century: lessons from the COVID-19 pandemic. BMJ Glob Health. 2021;6(4):e004882. doi:10.1136/bmjgh-2020-004882 - DOI - PMC - PubMed
    1. Gianicolo E, Riccetti N, Blettner M, Karch A. Epidemiological measures in the context of the COVID-19 pandemic. Dtsch Arztebl Int. 2020;117(19):336-342. doi:10.3238/arztebl.2020.0336 - DOI - PubMed
    1. Grote U, Arvand M, Brinkwirth S, et al.. Measures to cope with the COVID-19 pandemic in Germany: nonpharmaceutical and pharmaceutical interventions. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2021;64(4):435-445. doi:10.1007/s00103-021-03306-z - DOI - PMC - PubMed
    1. Walsh KA, Tyner B, Broderick N, et al.. Effectiveness of public health measures to prevent the transmission of SARS-CoV-2 at mass gatherings: a rapid review. Rev Med Virol. 2022;32(3):e2285. - PubMed
    1. Wang Z, Whittington J, Yuan HY, Miao H, Tian H, Stenseth NC. Evaluating the effectiveness of control measures in multiple regions during the early phase of the COVID-19 pandemic in 2020. Biosaf Health. 2021;3(5):264-275. doi:10.1016/j.bsheal.2021.09.002 - DOI - PMC - PubMed

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